153732-25-3

Basic information

• Product Name: TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE
• Synonyms: TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE
• CAS NO: 153732-25-3
• Molecular Formula: C₁₃H₁₈BrNO₂
• Molecular Weight: 300.2
• Mol File: 153732-25-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE(153732-25-3)
• EPA Substance Registry System: TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE(153732-25-3)

Safety Data

• Hazardous Substances Data: 153732-25-3(Hazardous Substances Data)

Upstream product

• 31938-07-5 (3-bromophenyl)acetonitrile 
• 151583-29-8 methyl 3-(3'-bromophenyl)-propionate 
• 3650-77-9 methyl 3-(3'-bromophenyl)-acrylate 
• 14473-91-7 3-bromocinnamic acid 
• 3132-99-8 m-bromobenzoic aldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 
• 58971-11-2 2-(3-bromophenyl)ethanamine 

Downstream Products

• 898271-34-6 tert-butyl [2-(3-cyanophenyl)ethyl]carbamate 
• 214964-28-0 2-amino-4'-(2-tert-butoxycarbonylaminoethyl)-5-chlorobenzophenone 
• 878158-09-9 trans-methyl 3-(3'-{2''-[3'''-(2''''-tert-butoxycarbonylaminoethyl)phenyl]vinyl}phenyl)-propionate 
• 878158-10-2 (E)-1-(3-(2-aminoethyl)phenyl)-2-(O-methyl hydrocinnam-3’-yl)-ethene 
• 878158-11-3 methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate 
• 878158-12-4 trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionic acid 
• 878158-08-8 [2-(3'-vinyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior

We have shown that CB1 receptor negative allosteric modulators (NAMs) attenuated the reinstatement of cocaine-seeking behaviors in rats. In an effort to further define the structure-activity relationships and assess the druglike properties of the 3-(4-chlorophenyl)-1-(phenethyl)urea-based CB1 NAMs that we recently reported, we introduced substituents of different electronic properties and sizes to the phenethyl group and evaluated their potency in CB1 calcium mobilization, cAMP, and GTPγS assays. We found that 3-position substitutions such as Cl, F, and Me afforded enhanced CB1 potency, whereas 4-position analogues were generally less potent. The 3-chloro analogue (31, RTICBM-189) showed no activity at >50 protein targets and excellent brain permeation but relatively low metabolic stability in rat liver microsomes. Pharmacokinetic studies in rats confirmed the excellent brain exposure of 31 with a brain/plasma ratio Kp of 2.0. Importantly, intraperitoneal administration of 31 significantly and selectively attenuated the reinstatement of the cocaine-seeking behavior in rats without affecting locomotion.

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed several classes of 2-aminoquinoline-based nNOS inhibitor

NOVEL HETEROARYL HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), ab (I), wherein R1 to R3 and L are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.