153733-80-3

Usage

Uses

Used in Organic Synthesis:
Naphthalene, 1-(2-methyl-1H-inden-4-yl)is utilized as a reagent in organic synthesis for the preparation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Naphthalene, 1-(2-methyl-1H-inden-4-yl)is employed as a precursor to develop new drugs. Its chemical properties enable the creation of novel therapeutic agents that can target specific biological pathways or receptors, potentially leading to the discovery of innovative treatments for various diseases.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, Naphthalene, 1-(2-methyl-1H-inden-4-yl)- serves as a starting material for the development of new pesticides or herbicides. Its structural features can be manipulated to create molecules with specific modes of action, contributing to the advancement of crop protection strategies.
Used in Fragrance Production:
Due to its aromatic properties, Naphthalene, 1-(2-methyl-1H-inden-4-yl)can be used in the production of fragrances. Its unique scent profile can be incorporated into perfumes, cosmetics, or other scented products, adding depth and complexity to the final product.
Used in Dyes and Pigments Industry:
Naphthalene, 1-(2-methyl-1H-inden-4-yl)-'s aromatic nature also makes it suitable for use in the production of dyes and pigments. Its color and stability can be harnessed to create vibrant and long-lasting colors for various applications, such as textiles, plastics, or paints.
Safety Precautions:
Given its toxic nature, Naphthalene, 1-(2-methyl-1H-inden-4-yl)should be handled with care to prevent inhalation or ingestion. Proper safety measures, such as wearing protective gear and working in well-ventilated areas, should be implemented to minimize exposure and ensure the safety of those working with Naphthalene, 1-(2-methyl-1H-inden-4-yl)-.

Synthetic route

2-methyl-7-(1-naphthyl)-1-indanone (213381-57-8) → 2-Methyl-4-(1-naphthyl)indene (153733-80-3)

Conditions	Yield
With hydrogenchloride; sodium borohydrid; toluene-4-sulfonic acid In tetrahydrofuran; methanol; toluene

2-Methyl-4-(1-naphthyl)indene (153733-80-3) → C20H15(1-)*Li(1+)

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -70 - 20℃; Cooling with dry ice/methanol bath;

2-Methyl-4-(1-naphthyl)indene (153733-80-3) + dimethylsilicon dichloride (75-78-5) → chloro(2-methyl-4-naphth-1-yl-1H-inden-1-yl)dimethylsilane (198147-86-3)

Conditions	Yield
With n-butyllithium In tetrahydrofuran; 1,2-dimethoxyethane; toluene
Stage #1: 2-Methyl-4-(1-naphthyl)indene With n-butyllithium In tert-butyl methyl ether at -78 - 20℃; Stage #2: dimethylsilicon dichloride In tert-butyl methyl ether

2-Methyl-4-(1-naphthyl)indene (153733-80-3) → potassium (2-methyl-4-naphthyl)indenide

Conditions	Yield
With potassium hexamethylsilazane In hexane; toluene

2-Methyl-4-(1-naphthyl)indene (153733-80-3) + C31H45ClOSi → (6-(t-butoxy)hexyl)(4-(4-(t-butyl)phenyl)-2-methyl-1H-inden-1-yl)(methyl)(2-methyl-4-(naphthalen-1-yl)-1H-inden-1-yl)silane

Conditions	Yield
With copper(l) cyanide In hexane; tert-butyl methyl ether at 20℃; for 48h;

2-Methyl-4-(1-naphthyl)indene (153733-80-3) + 1,2-dimethyl-3H-benzo[b]cyclopenta[d]thiophene (445432-84-8) + diethyldichlorosilane (1719-53-5) → (1,2-dimethyl-3H-benzo[d]cyclopenta[b]thiophen-3-yl)diethyl(2-methyl-4-(naphthalen-1-yl)-1H-inden-1-yl)silane

Conditions	Yield
Stage #1: 1,2-dimethyl-3H-cyclopenta[b][1]benzothiophene With n-butyllithium In tetrahydrofuran at -25 - 20℃; for 3h; Stage #2: diethyldichlorosilane In tetrahydrofuran at -10 - 20℃; for 24h; Stage #3: 2-Methyl-4-(1-naphthyl)indene Further stages;

Upstream product

• 213381-57-8 2-methyl-7-(1-naphthyl)-1-indanone 

Relevant academic research and scientific papers

Preparation of preparing substituted indanones

a process for the preparation of indanones of the formula II from, indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling component.

Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound

Disclosed is a process for preparing a cyclopentadienyl group-containing silicon compound or a cyclopentadienyl group-containing germanium compound, comprising reacting (i) a lithium, sodium or potassium salt of a cyclopentadiene derivative with (ii) a silicon halide compound or a germanium halide compound in the presence of a cyanide or a thiocyanate. The cyanide or the thiocyanate is preferably a copper salt. According to the process of the invention, a cyclopentadienyl group-containing silicon compound or a cyclopentadienyl group-containing germanium compound, which is very useful for the preparation of a metallocene complex catalyst component, can be prepared in a high yield for a short period of time.