153748-64-2Relevant academic research and scientific papers
CARBAMOYL DERIVATIVES OF UNSUBSTITUTED 3(5)-AMINOPYRAZOLE
Razvodovskaya, L. V.,Erikova, M. V.,Putsykina, E. B.,Negrebetskii, V. V.,Grapov, A. F.
, p. 1145 - 1149 (2007/10/02)
Unsubstituted 3(5)-aminopyrazole reacts with various isocyanates or dialkylcarbamoyl chloride to give products of monocarbamoylation at the nitrogen atoms of the heteroring, 3-amino- and 5-amino-1-carbamoylpyrazoles or their mixture, depending on the structure of the carbamoylating agent.For the 3-chlorophenylaminocarbonyl derivative we showed the possibility of the 1,2-transition of the carbamoyl group and calculated thermodynamic parameters of this process.Aryl isocyanates react with 3(5)-aminopyrazole under severe conditions to give products of dicarbamoylation of the heteroring.
