15375-48-1Relevant articles and documents
Alkyl Chain Length Effects on the Photoionization of N-Alkylphenothiazines and Sulfonated Alkylphenothiazines in Anionic Alkyl Sulfate and Cationic Alkyltrimethylammonium Bromide Micelles
Kang, Young Soo,Baglioni, Piero,McManus, Hugh J. D.,Kevan, Larry
, p. 7944 - 7947 (1991)
The photoionization yields of N-alkylphenothiazines solubilized in either cationic or anionic micelles at 77 K were studied as a function of both alkyl and surfactant chain length.The results are compared to similar work on sulfonated N-alkylphenothiazines.The location of the phenothiazine moiety with respect to the micelle-water interface together with cation-water interactions is a major factor controlling the photoionization efficiency.The position of the N-alkylphenothiazine chromophore within a micelle can be altered by changing the alkyl chain length.The photoefficiency is also affected by the surface charge of the micelle.
Piezofluorochromic properties of AIE-active 9,10-bis(N-alkylpheno-thiazin- 3-yl-vinyl-2)anthracenes with different length of alkyl chains
Zheng, Meng,Sun, Mingxiao,Li, Yiping,Wang, Jianfeng,Bu, Lingyu,Xue, Shanfeng,Yang, Wenjun
, p. 29 - 34 (2014)
9,10-Bis(N-alkylphenothiazin-3-yl-vinyl-2)anthracenes (PT-Cn) with different carbon numbers (n) of alkyl chains (n = 2, 3, 5, 6, 7, 9, 12, 18) are prepared to further understand the effect of alkyl lengths on the solid-state fluorescence and piezochromic luminescence of alkyl-containing 9,10-bis(arylvinyl)anthracenes. The results show that the fluorescence emissions of both pressed and annealed PT-Cn are gradually blue-shifted, but the blue-shifted amplitudes of annealed states are more remarkable with the increase of alkyl length, leading to that longer alkyl-containing PT-Cn show larger piezofluorochromism (PFC) spectral shifts. Powder wide-angle X-ray diffraction and differential scanning calorimetry experiments reveal that the transformation between crystalline and amorphous states under various external stimuli is responsible for the PFC and restoration behaviors. This work demonstrates once again that combining the simple alternation of molecular chemical structure and the physical change of aggregate morphology under external stimuli could tune the solid-state optical properties of some organic fluorophores.
Photoionization of N-alkylphenothiazines in mesoporous metal silicoaluminophosphate molecular sieves
Bae, Jae Young,Ranjit, Koodali T.,Luan, Zhaohua,Krishna,Kevan, Larry
, p. 9661 - 9669 (2000)
The photoionization of N-alkylphenothiazines (PCn where n = 1, 3, 6, 10, and 16) in mesoporous silicoaluminophosphate (UHM-3) and transition metal-substituted silicoaluminophosphate (MUHM-3 where M = Cu, Ni, Cr, and Mn) molecular sieves has been studied by electron spin resonance with ultraviolet irradiation at room temperature. Mesoporous UHM-3 and MUHM-3 molecular sieves were synthesized at room temperature. The effect of the ratio of Si/Al, the nature of the transition metal, and the concentration of the metal on the photoyield was examined. N-Alkylphenothiazine was incorporated into these mesoporous materials and the photoionization of PCn was studied.
Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model
Yang, Wei,Liu, Xiaolong,Song, Chunli,Ji, Sen,Yang, Jianhong,Liu, Yang,You, Jing,Zhang, Jie,Huang, Shenzhen,Cheng, Wei,Shao, Zhenhua,Li, Linli,Yang, Shengyong
, (2021)
Ferroptosis is a new type of programmed cell death discovered recently and has been demonstrated to be involved in a number of human diseases such as ischemic stroke. Ferroptosis inhibitors are expected to have potential to treat these diseases. Herein, we report the identification of promethazine derivatives as a new type of ferroptosis inhibitors. Structure-activity relationship (SAR) analyses led to the discovery of the most potent compound 2-(1-(4-(4-methylpiperazin-1-yl)phenyl)ethyl)-10H-phenothiazine (51), which showed an EC50 (half maximal effective concentration) value of 0.0005 μM in the erastin-induced HT1080 cell ferroptosis model. In the MCAO (middle cerebral artery occlusion) ischemic stroke model, 51 presented an excellent therapeutic effect. This compound also displayed favorable pharmacokinetic properties, in particular, a good ability to permeate the blood-brain barrier. Overall, 51 could be a promising lead compound for the treatment of ferroptosis related diseases and deserves further investigations.
Reversible mechanochromism and aggregation induced enhanced emission in phenothiazine substituted tetraphenylethylene
Khan, Faizal,Ekbote, Anupama,Misra, Rajneesh
, p. 16156 - 16163 (2019)
Mono and tetra phenothiazine (PTZ) functionalized tetraphenylethylene (TPE) derivatives PTZTPE-1 and PTZTPE-4 were designed and synthesized by the Suzuki cross-coupling reactions between PTZ boronate ester and bromo TPEs. The PTZTPE-1 and PTZTPE-4 are hig
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Zaugg et al.
, p. 1389 (1958)
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White hyperelectrofluorescence from solution-processable OLEDs based on phenothiazine substituted tetraphenylethylene derivatives
Khan, Faizal,Urbonas, Ervinas,Volyniuk, Dmytro,Grazulevicius, Juozas V.,Mobin, Shaikh M.,Misra, Rajneesh
supporting information, p. 13375 - 13388 (2020/11/04)
Mechanochromic emitters with an appropriate combination of properties for white hyperfluorescent solution-processable organic light emitting diodes (OLEDs) were developed involving phenothiazine, tetraphenylethylene, and electron withdrawing (cyano (-CN))
