153776-13-7Relevant academic research and scientific papers
Synyhesis and computaional studies of some pyrimido[4,5:4,5]thieno[2,3-d] pyrimidine compounds
Mussa, Suliman M.,Ashoor, Salem El-T.,Albahi, Lamia A.
, p. 251 - 261 (2019/01/18)
The reaction of compound 1 with chloroacetamide in ethanol in the presence of excess amount of sodium acetate gave 5-Cyano-4-methyl-2-phenyl-6-acetamidethiopyrimidine (2), which upon treatment with sodium ethoxide in ethanol underwent intramolecular Thorp
SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, SUBSTITUTED THIENO[2,3-D:4,5-D']DIPYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, SUBSTITUTED PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND SUBSTITUTED FURO[2,3-D:4,5-D']DIPYRIMIDINE-2,4(1 H,3H)-DIONES AN
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Page/Page column 77, (2010/02/15)
The invention relates to novel pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=S), thieno[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=S), in addition to pyrido[3',2':4,5]furo[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=0) and furo[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=O) of general formulae 1a and 1b. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or tautomers thereof and physiologically compatible salts which can be produced therefrom and/or solvates thereof, in addition to the pharmaceutical use of said compounds, tautomers thereof, salts or solvates, as inhibitors of TNFa-release.
SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS
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Page/Page column 44, (2010/11/24)
The invention relates to novel agents of formula (I), where R1 = aryl, optionally substituted with C1 to C5 alkyl, C2 to C5 alkenyl, C1 to C5 O-alkyl, aryloxy (O-aryl), C1/
An easy direct conversion of pyridine- and pyrimidine-thiones into multi-fused heterocyclic compounds
Erian, Ayman Wahba,Abu-Shanab, Fathi Ali
, p. 2387 - 2391 (2007/10/03)
The reaction of azine-thiones with ethyl chlorofluoroacetate afforded 2- fluorothienoazines. The latter underwent self-condensation and gave multi- fused heterocyclic compounds. A wide range of unique heterocycles could be obtained on treatment of 2-fluorothienoazines with nitrogen nucleophilic reagents. The reactivity of the pyrimidine-thiones towards a variety of electrophilic reagents was studied. Chemical and spectroscopic evidence of the newly synthesized compounds are described.
Synthesis of 2,3-dihydro-imidazo[1,2-d]pyrimido[5',4':4.5]thieno[2,3-e]pyrimidines and 2H-3,4-dihydro-pyrimido[1,2-c]pyrimido[5',4':4,5]thieno[2,3-e]pyrimidi nes
Wagner,Vieweg,Leistner
, p. 588 - 591 (2007/10/02)
The reaction of dibenzoyldiacetonitrile with cyanothioacetamide gave 5-cyano-6-methyl-2-phenyl-pyrimid-4(3H)-thione (4) in good yield. The title compounds were synthesized on two different routes. On one way, 3-amino-thieno[2,3-d]pyrimidine-2-carbonic acid alkylesters obtained from 4 were after acetylation of the amino group to 9 transformed by reaction of aminoethanol to the hydroxy ethylated pyrimidothienopyrimidone 10b. This compound after chlorination to 11 by reaction with 1,2-diaminoethan or 1,3-diaminopropan yielded the desired tetracyclic substances 12 and 13. On the other way, 3-aminothieno[2,3d]pyrimidine-2-carboxamide 14 obtained from 4 gave via the pyrimidothienopyrimidone 15, the chloro compound 17 and the ω-hydroxyalkyl compounds 21 and 22 the title substances 23 and 24.
