153776-15-9

Upstream product

• 2228-12-8 6-methyl-4-phenyl-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile 
• 108-24-7 acetic anhydride 
• 153776-13-7 5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidin-6-carboxamide 

Downstream Products

• 153776-17-1 4-Chlor-2,9-dimethyl-7-phenyl-thieno<2,3-d:4,5-d'>dipyrimidin 

Relevant academic research and scientific papers

Synthesis of 2,3-dihydro-imidazo[1,2-d]pyrimido[5',4':4.5]thieno[2,3-e]pyrimidines and 2H-3,4-dihydro-pyrimido[1,2-c]pyrimido[5',4':4,5]thieno[2,3-e]pyrimidi nes

The reaction of dibenzoyldiacetonitrile with cyanothioacetamide gave 5-cyano-6-methyl-2-phenyl-pyrimid-4(3H)-thione (4) in good yield. The title compounds were synthesized on two different routes. On one way, 3-amino-thieno[2,3-d]pyrimidine-2-carbonic acid alkylesters obtained from 4 were after acetylation of the amino group to 9 transformed by reaction of aminoethanol to the hydroxy ethylated pyrimidothienopyrimidone 10b. This compound after chlorination to 11 by reaction with 1,2-diaminoethan or 1,3-diaminopropan yielded the desired tetracyclic substances 12 and 13. On the other way, 3-aminothieno[2,3d]pyrimidine-2-carboxamide 14 obtained from 4 gave via the pyrimidothienopyrimidone 15, the chloro compound 17 and the ω-hydroxyalkyl compounds 21 and 22 the title substances 23 and 24.