153787-16-7Relevant academic research and scientific papers
Highly Carbon-Selective Monofluoromethylation of β-Ketoesters with Fluoromethyl Iodide
Ding, Tianqi,Jiang, Lvqi,Yang, Jie,Xu, Yimin,Wang, Guixiang,Yi, Wenbin
supporting information, p. 6025 - 6028 (2019/08/20)
A highly carbon-selective monofluoromethylation of a broad range of β-ketoesters with fluoromethyl iodide under mild conditions is described. The uses of lithium tert-butoxide as the base and diglyme as the solvent made great contributions to the high C/O regioselectivity.
5-AMINO-4-CARBAMOYL-PYRAZOLE COMPOUNDS AS SELECTIVE AND IRREVERSIBLE T790M OVER WT-EGFR KINASE INHIBITORS AND USE THEREOF????
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Paragraph 0223, (2016/03/13)
Disclosed are compounds of Formula (I), pharmaceutical compositions comprising the same, processes for the preparation thereof, and the use thereof.
Regioswitchable Palladium-Catalyzed Decarboxylative Coupling of 1,3-Dicarbonyl Compounds
Kenny, Miles,Christensen, Jeppe,Coles, Simon J.,Franckeviius, Vilius
supporting information, p. 3926 - 3929 (2015/08/19)
A palladium-catalyzed chemo- and regioselective coupling of 1,3-dicarbonyl compounds via an allylic linker has been developed. This reaction, which displays broad substrate scope, forms two C-C bonds and installs two all-carbon quaternary centers. The regioselectivity of the reaction can be predictably controlled by utilizing an enol carbonate of one of the coupling partners.
Convenient synthesis of chromones and quinolinones
Hemavathi,Naveen,Lokanatha Rai
, p. 409 - 410 (2013/09/24)
A one pot synthesis of substituted chromones and quinolinones by condensing commercially available and cheaper molecules like salicylic acid and anthranilic acid respectively with alkenes / nitriles followed by insitu cyclization using ammonium acetate as base has been achieved.
