1537906-38-9Relevant academic research and scientific papers
Selective alkylation and arylation of C-F bond with grignard reagents
Lu, Faguan,Sun, Hongjian,Du, Aiqin,Feng, Lei,Li, Xiaoyan
, p. 772 - 775 (2014/03/21)
Selective alkylation and arylation of the C-F bonds of polyfluoroaryl imines with Grignard reagents were discovered in the absence of metal catalysts. The aldazine-N atom as an anchoring group has a special effect on the regioselectivity of the reaction. The Ci - N bond addition reaction with Grignard reagents was also explored. A possible mechanism was proposed on the competition between the nucleophilic substitution and addition reaction.
