153850-88-5

Basic information

• Product Name: 4'-CHLORO-BIPHENYL-2-METHANAMINE
• Synonyms: 4'-CHLORO-BIPHENYL-2-METHANAMINE;(4-chloro-1,1-biphenyl-2-yl)methylamine
• CAS NO: 153850-88-5
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Mol File: 153850-88-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-CHLORO-BIPHENYL-2-METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-CHLORO-BIPHENYL-2-METHANAMINE(153850-88-5)
• EPA Substance Registry System: 4'-CHLORO-BIPHENYL-2-METHANAMINE(153850-88-5)

Safety Data

• Hazardous Substances Data: 153850-88-5(Hazardous Substances Data)

Upstream product

• 2042-37-7 o-cyanobromobenzene 
• 4387-36-4 2-iodobenzonitrile 
• 1679-18-1 4-Chlorophenylboronic acid 
• 89346-58-7 4′-chloro-1,1′-biphenyl-2yl-carbonitrile 
• 3959-05-5 2-bromobenzylamine 

Downstream Products

• 1360593-20-9 3-chlorophenanthridine 

Relevant articles and documents

Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

Highly substituted fluorenones are readily prepared in mostly fair to good yields via metal- and additive-free TBHP-promoted cross-dehydrogenative coupling (CDC) of readily accessible N-methyl-2-(aminomethyl)biphenyls and 2-(aminomethyl)biphenyls. This methodology is compatible with numerous functional groups (methoxy, cyano, nitro, chloro, and SEM and TBS-protective groups for phenols) and was further utilized in the first total synthesis of the natural product nobilone.

Synthesis of phenanthridines through iodine-supported intramolecular C-H amination and oxidation under visible light

Herein, we report a metal-free and step-economic synthesis of phenanthridines from 2-biarylmethanamines under mild conditions. The reaction involves iodine-supported intramolecular C-H amination and oxidation of 5,6-dihydrophenanthridine under air and benign visible light. The mechanism study reveals that visible light plays a key role in both these steps.