153850-93-2Relevant academic research and scientific papers
Reactions of Diene-conjugated 1,3-Dipolar Intermediates: A Versatile and Efficient Route to Dibenzazepines via Benzonitrile o-Arylbenzyl Ylides
Cullen, Kevin E.,Sharp, John T.
, p. 2961 - 2968 (2007/10/02)
Diene-conjugated nitrile ylides of the type 1 in which both the α,β- and the γ,δ-double bonds are aromatic and where R is either hydroger or a para substitutent, cyclise to give dibenzazepines21 (Scheme 2) in high yield.This is in contrast to the analogous diazo system 2 in which cyclisation do not occur.The presence of an ortho methyl group in the ring under attack (1j, Scheme 3) prevents cyclisation via its steric limitations of conjugation in the transition state.
