15386-52-4

Usage

Structure

A derivative of 1,2-benzenediol with a thiazole ring and an amino group at the 2-position.

Biological activity

Potential biological activity, which may be useful in pharmaceutical research or drug development.

Structural features

Thiazole ring and amino group at the 2-position contribute to the compound's potential pharmacological properties.

Further research

Additional study may be needed to fully understand the potential uses and effects of this chemical compound.

Upstream product

• 99-40-1 2-chloro-3',4'-dihydroxyacetophenone 
• 17356-08-0 thiourea 
• 67-64-1 acetone 
• 22776-09-6 1-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)ethan-1-one 
• 306935-51-3 4-(3,4-dihydro-2H-benzo[b]1,4-dioxepin-7-yl)thiazol-2-amine 
• 7216-18-4 3,4-dihydro-2H-benzo[b][1,4]dioxepine 
• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 120-80-9 benzene-1,2-diol 
• 64-17-5 ethanol 

Downstream Products

• 26245-51-2 1-(4-bromo-phenyl)-3-[4-(3,4-dihydroxy-phenyl)-thiazol-2-ylamino]-propan-1-one 
• 26245-49-8 3-[4-(3,4-dihydroxy-phenyl)-thiazol-2-ylamino]-1-phenyl-propan-1-one 
• 85849-80-5 N-[4-(3,4-Dihydroxy-phenyl)-thiazol-2-yl]-oxalamic acid 

Relevant academic research and scientific papers

An efficient strategy for protecting dihydroxyl groups of catechols

A novel strategy for protecting dihydroxyl groups of catechols has been developed. Base-mediated cyclizations of catechols with 1,3-dibromopropane provided the corresponding benzo[b]1,4-dioxepans, and herefrom the protecting group was easily cleaved by aluminum chloride. The preparation of the antibacterial and antifungal agent 4-(2-aminothiazol-4-yl)benzene-1,2-diol from catechol reliably verified its availability amenable to various harsh reaction conditions. Georg Thieme Verlag Stuttgart - New York.

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Methionine aminopeptidase (MetAP) is a promising target to develop novel antibiotics, because all bacteria express MetAP from a single gene that carries out the essential function of removing N-terminal methionine from nascent proteins. Divalent metal ion

Synthesis of some new 4-{2-[(aryl)amino]-1,3-thiazol-4-yl}benzene-1,2-diols as possible antibacterial and antifungal agents

Some new 4-{2-[(aryl) amino]-1,3-thiazol-4-yl}benzene-1,2-diols are prepared and characterized by spectral analysis. The newly prepared compounds are studied for their antibacterial and antifungal activity. Interestingly, almost all the compounds are found to possess promising antibacterial and antifungal activity against all tested microorganisms. Copyright Taylor & Francis Group, LLC.

N-(4-Substituted-thiazolyl)oxamic Acid Derivatives, a New Series of Potent, Orally Actve Antiallergy Agents

A series of N-(4-substituted-thiazolyl)oxamic acid derivatives were synthesized and tested for antiallergy activity in the rat PCA model.These compounds were conveniently prepared by treatment of the appropriate acetophenone with thiourea and iodine or by reaction of the chloroacetylbenzene with thiourea to give the corresponding aminothiazoles; subsequent condensation with ethyloxalyl chloride gave the thiazolyloxamates.Many of the analogues showed a 50percent inhibition at oxamic acid ethanolamine salt (61, PRH-836-EA), has been selected for further pharmacological evaluation.