1538607-45-2Relevant academic research and scientific papers
Fe(OTf)3 catalyzed annulation of 2,3-disubstituted indoles with aziridines
Liu, Hua,Zheng, Chao,You, Shu-Li
, p. 709 - 714 (2014/10/16)
A Fe(OTf)3 catalyzed [3＋2] annulation reaction between 2,3-disubstituted indoles and N-Ts aziridines is described herein. A series of hexahydropyrrolo[3,4-b]indole derivatives bearing two consecutive quaternary carboncenters can be generated efficiently. The reaction features cheap catalyst, mild conditions and operational simplicity.
Catalytic C6 functionalization of 2,3-disubstituted indoles by scandium triflate
Liu, Hua,Zheng, Chao,You, Shu-Li
, p. 1047 - 1054 (2014/03/21)
We report herein an unprecedented direct catalytic C6 functionalization reaction of 2,3-disubstituted indoles with various N-Ts aziridines catalyzed by Sc(OTf)3 under mild conditions. Mechanistic studies revealed that a kinetically favored but reversible formal [3 + 2] annulation occurs initially. The direct C6 functionalization, although having a relatively higher energetic barrier, delivers the thermodynamically favorable products.
