153931-80-7

Upstream product

• 5334-43-0 5-Amino-4-cyano-1-phenylpyrazole 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 153931-92-1 dimethyl 1-phenylpyrazolo<3,4-b>pyridine-5,6-dicarboxylate 
• 153931-86-3 1-phenylpyrazolo<3,4-b>pyridine-5,6-biscarbohydrazide 
• 153931-87-4 1-phenylpyrazolo<4',3':5,6>pyrido<2,3-d>pyridazine-5,8(6H,7H)-dione 
• 153931-89-6 5,8-dichloro-1-phenylpyrazolo<4',3':5,6>pyridazine 

Relevant academic research and scientific papers

PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF

This invention relates with the arylheterocycle-fused pyrimidines, derivatives and analogs of formula I: or stereoisomers, tautoers, prodrugs, pharmaceutically acceptable salts, complex salts or solvates thereof, wherein: A-cycle is of 3-8 saturated or unsaturated arylheterocycles or aliheterocyclic, containing 1-4 heteroatoms, B-cycle 5-8 member saturated or unsaturated heterocycle containing 1-4 heteroatoms; X1, X2, X3, X4 are, independently at each occurrence, C, O, S, Se, N and P elements; R1, R2, R3 is a substituent containing alicyclic group, arylcycle group, heterocyclic group, adamantane alkyl, adamantane heterocycle, adamantane analogs, sugar group, hydroxyl group, amino acid group or a combination of the above substituents. This invention also relates with their preparative methods and applications.

Reaction of 5-Amino-1-phenylpyrazole-4-carbonitriles with Dimethyl Acetylenedicarboxylate. Synthesis and Structural Determination of Trimethyl 4,8-Dioxo-1-phenyl-4,5,5a,8-tetrahydro-1H-pyrazolo[3,4-e]indolizine-5,5a,6- tricarboxylate Derivatives

The reaction of 5-amino-1-phenylpyrazole-4-carbonitriles 1a-c with dimethyl acetylenedicarboxylate in the presence of potassium carbonate in dimethyl sulfoxide gave trimethyl 4,5,5a,8-tetrahydro-1-phenyl-4,8-dioxo-1H-pyrazolo[3,4-e]indolizine-5,5a,6- tric

Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4',3':5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-diones and related compounds

Reactions of 1,3-disubstituted 5-aminopyrazole 5-aminopyrazole-4-carbonitrile derivatives (3a-o) with dimethyl acetylenedicarboxylate in the presence of potassium carbonate in dimethyl sulfoxide gave the corresponding dimethyl 1,3-disubstituted pyrazolo[3,4-b]pyridine-5,6-dicarboxylates (4a-o) which were allowed to react with excess hydrazine hydrate in ethanol under reflux followed by heating at 250-300°C to give 1,3-disubstituted 4-amino-1H-pyrazolo[4',3':5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-dione s (7a-s) in good yields. These tricyclic pyridazine derivatives were evaluated for chemiluminescence. Some were found to be more efficient than luminol in light production. 4-Amino-3-methylsulfonyl-1-phenyl-1H-pyrazolo[4',3':5,6]pyrido[2,3-d]p yridazine-5,8(6H,7H)-dione (7r) showed the greatest chemiluminescence intensity derivatives in the presence of H2O2, peroxidase, in a solution of phosphate buffer pH 8.0.

Polycyclic Pyridazines. II. Synthesis of Pyrazolopyridopyridazine Derivatives from Dimethyl Pyrazolopyridazine-5,6-dicarboxylates as the Key Intermediates

The synthesis of the novel pyrazolopyridopyridazine ring system and some of its derivatives has been accomplished such as 4-amino-1-phenyl-5,8-dioxo-, 4-amino-5,8-dioxo-, 1-phenyl-5,8-dioxo-, 5,8-dioxo-, 5,8-dichloro-1-phenyl-, 5-ethoxy-1-phenyl- and 8-ethoxy-1-phenylpyrazolopyridopyridazines.