1539318-36-9 Usage
Uses
Used in Biomedical Research:
DFHBI 1T is used as a fluorescent probe for imaging RNA in living cells. Its application is based on its ability to mimic the properties of GFP fluorophore, allowing researchers to visualize and track RNA molecules within cellular environments. This capability is crucial for understanding various cellular processes and mechanisms, as well as for the development of new therapeutic strategies targeting RNA.
Used in Drug Delivery Systems:
In the field of drug delivery, DFHBI 1T can be employed as a component in the design of novel drug delivery systems. Its fluorescent properties can be utilized to monitor the release and distribution of therapeutic agents within the body, providing valuable insights into the effectiveness and safety of these systems.
Used in Diagnostic Applications:
DFHBI 1T can also be used in the development of diagnostic tools and assays, where its fluorescence can be harnessed to detect specific RNA biomarkers associated with various diseases. This application can aid in the early detection and monitoring of disease progression, ultimately leading to improved patient outcomes.
Used in Pharmaceutical Development:
In the pharmaceutical industry, DFHBI 1T can be used as a starting point for the development of new drugs targeting RNA-based therapeutics. Its unique chemical structure and fluorescent properties can be exploited to design molecules with enhanced specificity and efficacy, potentially leading to the discovery of novel therapeutic agents for a wide range of diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1539318-36-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,9,3,1 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1539318-36:
(9*1)+(8*5)+(7*3)+(6*9)+(5*3)+(4*1)+(3*8)+(2*3)+(1*6)=179
179 % 10 = 9
So 1539318-36-9 is a valid CAS Registry Number.
1539318-36-9Relevant articles and documents
Plug-and-play fluorophores extend the spectral properties of spinach
Song, Wenjiao,Strack, Rita L.,Svensen, Nina,Jaffrey, Samie R.
supporting information, p. 1198 - 1201 (2014/02/14)
Spinach and Spinach2 are RNA aptamers that can be used for the genetic encoding of fluorescent RNA. Spinach2 binds and activates the fluorescence of (Z)-4-(3,5-difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one (DFHBI), allowing the dynamic localizations of Spinach2-tagged RNAs to be imaged in live cells. The spectral properties of Spinach2 are limited by DFHBI, which produces fluorescence that is bluish-green and is not optimized for filters commonly used in fluorescence microscopes. Here we characterize the structural features that are required for fluorophore binding to Spinach2 and describe novel fluorophores that bind and are switched to a fluorescent state by Spinach2. These diverse Spinach2-fluorophore complexes exhibit fluorescence that is more compatible with existing microscopy filter sets and allows Spinach2-tagged constructs to be imaged with either GFP or YFP filter cubes. Thus, these plug-and-play fluorophores allow the spectral properties of Spinach2 to be altered on the basis of the specific spectral needs of the experiment.
