153939-65-2Relevant academic research and scientific papers
Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids
Buckle,Cantello,Cawthorne,Coyle,Dean,Faller,Haigh,Hindley,Jefcott,Lister,Pinto,Rami,Smith,Smith
, p. 2121 - 2126 (1996)
The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids. α-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the α-ethoxyacid 15 (SB 213068), is one of the most potent antihyperglycaemic agents yet reported.
Heterocyclic compounds and their use in the treatment of Type-II diabetes
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, (2008/06/13)
A compound of the formula A1 --X--(CH2)n --O--A2 --A3 --CO.R2 (I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; A2 represents a benzene ring having three optional substituents; A3 represents a moiety of formula --(CH2)m --CHR1 -- wherein R1 represents a halogen atom or a moiety of formula S(O)p A4 wherein A4 represents hydrogen, substituted or unsubstituted alkyl, aryl, aralkyl, alkylcarbonyl or an aromatic heterocyclyl group and p represents zero or an integer 1 or 2 and m represents zero or an integer in the range of from 1 to 5, or A3 represents a moiety of formula --CH=CR1 -- wherein R1 is as defined above; R2 represents OR3 wherein R3 represents hydrogen, alkyl, aryl or aralkyl, or R2 represents --NR4 R5 wherein R4 and R5 each independently represent hydrogen or alkyl or R4 and R5 together with the nitrogen atom to which they are attached form a heterocyclic ring; X represents O, S or NR wherein R represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; and n represents an integer in the range of from 2 to 6; a process for the preparation of such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound and composition in medicine.
