Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids

DOI: 10.1016/0960-894X(96)00383-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2121 - 2126 (1996)

Update date:2022-08-05

Topics:

Authors:

Buckle Buckle

Cantello

Cawthorne

Coyle Coyle

Dean Dean

Faller Faller

Haigh Haigh

Hindley Hindley

Jefcott Jefcott

Lister Lister

Pinto Pinto

Rami Rami

Smith Smith

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Article abstract of DOI:10.1016/0960-894X(96)00383-6

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids. α-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the α-ethoxyacid 15 (SB 213068), is one of the most potent antihyperglycaemic agents yet reported.

Full text of DOI:10.1016/0960-894X(96)00383-6

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