Bioorganic and Medicinal Chemistry Letters p. 2121 - 2126 (1996)
Update date:2022-08-05
Topics:
Buckle
Cantello
Cawthorne
Coyle
Dean
Faller
Haigh
Hindley
Jefcott
Lister
Pinto
Rami
Smith
Smith
The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids. α-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the α-ethoxyacid 15 (SB 213068), is one of the most potent antihyperglycaemic agents yet reported.
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