153944-51-5Relevant articles and documents
Synthesis of the lipophilic antifolate piritrexim via a palladium(0)-catalyzed cross-coupling reaction
Chan, David C. M.,Rosowsky, Andre
, p. 1364 - 1368 (2005)
(Chemical Equation Presented) A regiospecific and convergent route the lipophilic antifolate piritrexim (PTX) is described in which a key step is a Pd(0)-catalyzed cross-coupling reaction between 2-amino-3-cyano-4-methyl-5- bromopyridine and 2,5-dimethoxy