15398-00-2

Usage

Structure

A five-membered aromatic ring with one nitrogen atom and two 4-methylphenyl groups attached to positions 2 and 4 of the pyrrole ring.

Type of compound

Pyrrole derivative, which is a heterocyclic aromatic compound.

Usage

Mainly used in research and development, as well as a building block in the synthesis of pharmaceuticals and agrochemicals.

Hazard classification

Classified as a hazardous substance.

Health hazards

Can cause irritation to the skin, eyes, and respiratory system upon exposure.

Safety precautions

Proper handling and safety precautions should be taken when working with this chemical.

Upstream product

• 32687-33-5 3-p-tolyl-2H-azirine 
• 97691-66-2 1,3-bis(4-methylphenyl)prop-2-yn-1-one 
• 152801-73-5 2-bromo-1-p-tolylethanone O-methyl oxime 
• 6595-30-8 2-azido-1-(4-methylphenyl)ethan-1-one 

Relevant academic research and scientific papers

SmI2-mediated synthesis of 2,4-diarylpyrroles from phenacyl azides

A novel reduction of phenacyl azides induced by SmI2 was investigated and 2,4-diarylpyrroles were prepared in moderate to good yields under mild conditions.

Base-promoted ring-closing carbonyl-allene metathesis for the synthesis of 2,4-disubstituted pyrroles

A base-promoted ring-closing carbonyl-allene metathesis reaction of N-allenyl β-enaminones (generated in situ from N-propargyl β-enaminones) gives 2,4-disubstituted pyrroles with cleavage of the C(sp)-C(sp3) bond. This transition metal-free procedure generates 1 equiv. of acetic acid as the sole byproduct. A preliminary mechanistic study supports a stepwise [2 + 2] cycloaddition/retro [2 + 2] reaction pathway.

Ytterbium-mediated synthesis of 2,4-diarylpyrroles from α-bromo oxime ethers

A novel and efficient ytterbium promoted reductive cyclisation dimerization of α-bromo-oxime ethers affording 2,4-diarylpyrroles with high regioselectivity has been developed. Compared with the reported synthesis methods, the method has the following advantages: readily available and safe starting material, one-pot single step operation and mild and neutral reaction conditions.

Reaction between 4-Nitro-1,3-diarylbutan-1-ones and Ammonium Acetate in the Presence of Morpholine and Sulfur: An Efficient Synthesis of 2,4-Diarylpyrroles

An efficient synthesis of 2,4-diarylpyrroles is described. Heating a mixture of a 4-nitro-1,3-diarylbutan-1-one and ammonium acetate in the presence of morpholine and sulfur afforded the corresponding 2,4-diarylpyrroles in excellent yields.

SmI2-mediated reduction of phenacyl azides: A novel preparation of 2,4-diarylpyrroles

A novel reductive cyclisation of phenacyl azides brought about by samarium iodide is described in this paper. By this process several 2,4-diarylpyrroles have been prepared.

NOVEL TYPES OF TRANSFORMATIONS OF α-AZIDOSTYRENE DERIVATIVES AND 3-ARYL-2H-AZIRINES IN THE PRESENCE OF HEXACARBONYLMOLYBDENUM

The reaction of α-azidostyrene derivatives with hexacarbonylmolybdenum was found to give 2,5-diarylpyrroles and acetophenone derivatives via a complexed 1-arylvinylnitrene intermediate, while that of 3-aryl-2H-azirines gave 2,4-diarylpyrroles in addition to acetophenone derivatives and 2,5-diarylpyrazines.