153982-08-2Relevant articles and documents
IIB/IIIA ANTAGONISTS CO-ADMINISTERED WITH ASPIRIN
-
, (2008/06/13)
The present invention is directed to coadministration of the fibrinogen receptor antagonists 3S-[[4-[[4-aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoic acid or ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-penty
Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation
-
, (2008/06/13)
This invention provides a compound of the formula or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of treatment to inhibit aggregation of platelets.
Peptide mimics useful as platelet aggregation inhibitors
-
, (2008/06/13)
This invention relates to compounds having the following formula STR1 or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp sequence of fibrinogen. (Aminobenzamidino)succinyl (ABAS) series of orally active fibrinogen receptor antagonists
Zablocki,Rico,Garland,Rogers,Williams,Schretzman,Rao,Bovy,Tjoeng,Lindmark,Toth,Zupec,McMackins,Adams,Miyano,Markos,Milton,Paulson,Herin,et al.
, p. 2378 - 2394 (2007/10/02)
Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our iv antiplatelet agent (SC-52012) demonstrated modest oral activity in canine studies (ethyl [5-(4-amidinophenyl)penta
Substituted β-amino acid derivatives useful as platelet aggregation inhibitors
-
, (2008/06/13)
Novel substituted β amino acid derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
-
, (2008/06/13)
Novel substituted heterocyclic derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
-
, (2008/06/13)
Novel substituted β amino acid derivatives are provided which inhibit platelet aggregation and intermediates thereof. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.