153985-33-2

Upstream product

• 594-56-9 2,2,3-trimethylbut-1-ene 
• 83021-21-0 L-menthyldichlorophosphine 

Downstream Products

• 190850-93-2 [(1R,2R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-yl]-acetaldehyde 
• 190952-55-7 (4R,5R)-2-[(1R,2R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-ylmethyl]-4,5-diphenyl-[1,3]dioxolane 
• 190952-70-6 (4S,5S)-2-[(1R,2R)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3,3,4,4-tetramethyl-1-oxo-1λ⁵-phosphetan-2-ylmethyl]-4,5-diphenyl-[1,3]dioxolane 
• 190850-91-0 (1R,4R)-4-Allyl-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-2,2,3,3-tetramethyl-phosphetane 1-oxide 
• 154096-79-4 P(R),C(R)-4-benzyl-1-menthyl-2,2,3,3-tetramethylphosphetane oxide 

Relevant academic research and scientific papers

Synthesis and characterization of some P-menthylphosphetanes, a new class of electron-rich chiral phosphines

1-Menthyl substituted phosphetane oxides 4 and 6 are prepared either by starting from (menthyl)PCl2 and an appropriate olefin, or by reacting (menthyl)MgCl with a 1-chlorophosphetane. Highly selective alkylation and halogenation reactions of the corresponding anions 4' afford α-substituted derivatives in diastereomerically pure form. Reductions of the phosphetane oxides with HSiCl3.Et3N proceed with retention of configuration about the phosphorus atom. The described procedure provide an access to a wide range of optically pure phosphines of known stereochemistry.