154096-79-4Relevant academic research and scientific papers
Synthesis and characterization of some P-menthylphosphetanes, a new class of electron-rich chiral phosphines
Marinetti,Ricard
, p. 10291 - 10304 (2007/10/02)
1-Menthyl substituted phosphetane oxides 4 and 6 are prepared either by starting from (menthyl)PCl2 and an appropriate olefin, or by reacting (menthyl)MgCl with a 1-chlorophosphetane. Highly selective alkylation and halogenation reactions of the corresponding anions 4' afford α-substituted derivatives in diastereomerically pure form. Reductions of the phosphetane oxides with HSiCl3.Et3N proceed with retention of configuration about the phosphorus atom. The described procedure provide an access to a wide range of optically pure phosphines of known stereochemistry.
