153993-87-4

Basic information

• Product Name: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-hydroxyethyl)phenyl>benzeneacetate
• CAS NO: 153993-87-4
• Molecular Weight: 486.651
• Mol File: 153993-87-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-hydroxyethyl)phenyl>benzeneacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-hydroxyethyl)phenyl>benzeneacetate(153993-87-4)
• EPA Substance Registry System: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-hydroxyethyl)phenyl>benzeneacetate(153993-87-4)

Safety Data

• Hazardous Substances Data: 153993-87-4(Hazardous Substances Data)

Upstream product

• 25726-04-9 phenylglyoxylyl chloride 
• 4654-39-1 4-bromophenethanol 
• 73899-15-7 1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane 
• 88002-15-7 Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester 
• 611-73-4 Benzoylformic acid 

Relevant articles and documents

Asymmetric synthesis of benzilic acid analogues using 8-phenylmenthol as a chiral auxiliary

Our program on the synthesis of 18F-labeled muscarinic receptor ligands required the preparation of chiral fluoroalkyl benzilic acids. An enantioselective synthesis of substituted benzilic acids was achieved using 8-phenylmenthol as the chiral auxiliary. Grignard addition to the si face of 8-phenylmenthyl benzoylformate 7 proceeded with high selectivity. The results of the chiral induction support assignments of the chirality of benzilic acids previously resolved by crystallization. The method was used to synthesize (R)-quinuclidinyl-(R)-4-iodo)benzilate, which proved identical to an authentic sample. In addition, the method allows the preparation of (R)- and (S)-fluoroethyl benzilic acids in a stereoselective manner.