154-69-8

Basic information

• Product Name: TRIPELENNAMINE HYDROCHLORIDE
• Synonyms: 2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride;2-ethanediamine,n,n-dimethyl-n’-(phenylmethyl)-n’-2-pyridinyl-monohydroc;dehistin;dehistinmonohydrochloride;n(sup1)-alpha-pyridyl-n(sup1)-benzyl-n,n-dimethylethylenediaminemonohydro;n,n-dimethyl-n’-(2-pyridyl)-n’-benzylethylenediaminehydrochloride;n-benzyl-n’,n’-dimethyl-n-(2-pyridyl)-ethylenediaminhydrochloride;n-benzyl-n’,n’-dimethyl-n-2-pyridyl-ethylenediaminehydrochloride
• CAS NO: 154-69-8
• Molecular Formula: C16H22ClN3
• Molecular Weight: 291.82
• EINECS: 205-833-5
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;API
• Mol File: 154-69-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 192-193℃
• Boiling Point: 387.8 °C at 760 mmHg
• Flash Point: 188.3 °C
• Appearance: White solid
• Density: 1.20
• Vapor Pressure: 3.21E-06mmHg at 25°C
• Storage Temp.: Refrigerator
• CAS DataBase Reference: TRIPELENNAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIPELENNAMINE HYDROCHLORIDE(154-69-8)
• EPA Substance Registry System: TRIPELENNAMINE HYDROCHLORIDE(154-69-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: US3150000
• Hazardous Substances Data: 154-69-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Tripelennamine is a first-generation antihistamine, used in the treatment of asthma, hay fever, and urticaria.

Brand name

PBZ (Novartis).

General Description

Different sources of media describe the General Description of 154-69-8 differently. You can refer to the following data:
1. Tripelennamine hydrochlorideis a white crystalline powder that darkensslowly on exposure to light. The salt is soluble in water(1:0.77) and in alcohol (1:6). It has a pKa of about 9, and a0.1% solution has a pH of about 5.5.Tripelennamine, the first ethylenediamine developed inthe United States and is well absorbed when given orally. Itappears to be as effective as diphenhydramine and may havethe advantage of fewer and less severe side reactions.Drowsiness may occur, however, and may impair the abilityto perform tasks requiring alertness. The concurrent use ofalcoholic beverages should be avoided.
2. Odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56.

Air & Water Reactions

Water soluble.

Reactivity Profile

TRIPELENNAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Fire Hazard

Flash point data for TRIPELENNAMINE HYDROCHLORIDE are not available; however, TRIPELENNAMINE HYDROCHLORIDE is probably combustible.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.

InChI:InChI=1/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

Synthetic route

hydrogenchloride (7647-01-0) + cobalt(II) chloride hexahydrate + tripelennamine hydrochloride (154-69-8) → N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II) (220156-62-7)

Conditions	Yield
In hydrogenchloride equimolar amts. of CoCl2 and ligand, 6 M HCl; crystn. overnight, washing (EtOH), recrystn. (MeCN, room temp., slow evapn);

tripelennamine hydrochloride (154-69-8) + cucurbit[7]uril → tripelennamine monohydrochloride-cucurbit[7]uril 1:1 complex

Conditions	Yield
In water pH=8;

Downstream Products

• 220156-62-7 N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II) 

Related news

Electro‐oxidation and Determination of TRIPELENNAMINE HYDROCHLORIDE (cas 154-69-8) at MWCNT‐CTAB Modified Glassy Carbon Electrode09/28/2019

An electrochemical method for the determination of tripelennamine hydrochloride (TPA) using cetyltrimethylammoniumbromide‐multiwalled carbon nanotubes modified glassy carbon electrode (MWCNT‐CTAB/GCE) was developed. Because of good electrical conductivity of MWCNT and catalytic behavior of CTA...detailed