154012-99-4

Upstream product

• 100-52-7 benzaldehyde 
• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 943009-82-3 ethyl 2-p-methoxybenzoyl-3-phenylacrylate 

Downstream Products

• 943009-83-4 C₂₀H₂₀O₄ 
• 943009-92-5 C₁₉H₂₀O₃ 

Relevant academic research and scientific papers

Friedel-Crafts Coordinated Processes: 1-Oxoindanes from Aromatic β-Dicarbonyl Compounds and Aldehydes

Variously substituted 1-oxoindanes were synthesized by highly selective bis-alkylation of aromatic β-dicarbonyl compounds with non enolizable aldehydes. - Key words: 1-Oxoindanes; β-dicarbonyl chelates; vicinal bis-alkylation.

Indane modulators of glucocorticoid receptor, AP-1, and/or NF/kB activity and use thereof

Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I): or enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, where X is -A1QA2-; Q is a bond, —C(═O)—, —OC(O)—, —C(═O)NR5—, —SOp—, —SOpNR5—, —C(O)O—, —NR5C(O)—, —OC(O)NR5—, —NR5C(O)O—, —S(O)pNR5C(O)—, —C(O)NR5S(O)p— —NR5S(O)p—, or —NR5C(═O)NR6—. Y is selected from hydrogen, C1-4alkyl, OR16, substituted C1-6alkyl, cycloalkyl, aryl, heterocyclo and heteroaryl. A1 and A2 are independently selected from a bond, C1-3alkylene, or C1-3alkenylene, and R1-R11 are defined herein. Also provided are pharmaceutical compositions, combinations, and methods of treating obesity, diabetes and inflammatory- or immune-associated diseases comprising said compounds.

Selective synthesis of 1-indanones via tandem Knoevenagel condensation-cycloalkylation of β-dicarbonyl compounds and aldehydes

Aromatic 1,3-dicarbonyl compounds react with not enolizable aldehydes in the presence of C2H5MgBr or AlCl3 affording 2-carbethoxy- and 2-acetyl-1-indanones via tandem, Knoevenagel condensation-cycloalkylation process.