138660-08-9Relevant academic research and scientific papers
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase
Cui, Huaqing,Ruda, Gian Filippo,Carrero-Lérida, Juana,Ruiz-Pérez, Luis M.,Gilbert, Ian H.,González-Pacanowska, Dolores
experimental part, p. 5140 - 5149 (2010/11/19)
Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) has a central role in purine salvage and inhibitors of the enzyme have been shown to have antiplasmodial activity. The enzyme preferentially uses inosine as substrate (Km = 5 μM, ks
Synthesis of a New Class of Uridine Phoshorylase Inhibitors
Tzeng, Cherng-Chyi,Panzica, Raymond P.,Naguib, Fardos N.M.,Kouni, Mahmoud H. el
, p. 1399 - 1404 (2007/10/02)
A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid.Among them 1--5-(m-benzyloxy)benzylbarbituric acid (37, BBBA) is the most promising having a Ki value of 1.1 +/- 0.2 nM wit
