154078-76-9Relevant academic research and scientific papers
Relationships between Structure and Kinetics of Cyclization of 2-Aminoaryl Amides: Potential Prodrugs of Cyclization-Activated Aromatic Mustards
Atwell, Graham J.,Sykes, Bridget M.,O'Connor, Charmian J.,Denny, William A.
, p. 371 - 380 (2007/10/02)
2-Nitroaryl amides of general structure I are proposed as bioreducible prodrugs, capable of releasing cytotoxic aminoaniline mustards V on bioactivation by spontaneous cyclization of the resulting 2-aminoaryl amides II via a tetrahedral intermediate, III.
