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154094-89-0

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154094-89-0 Usage

General Description

2-[3-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-2-nitro-2H-imidazol-1-y l]acetamide is a chemical compound that contains a nitroimidazole core and an acetamide functional group. It is commonly used as an antimicrobial agent, particularly in the treatment of bacterial and parasitic infections. The compound has been found to have activity against a wide range of microorganisms, including protozoa and anaerobic bacteria. Its mechanism of action involves the disruption of DNA synthesis and cell division in these organisms. Additionally, the compound has shown potential in the treatment of certain types of cancer, as it can selectively target hypoxic tumor cells. Therefore, 2-[3-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-2-nitro-2H-imidazol-1-y l]acetamide is a versatile and important chemical with promising applications in medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 154094-89-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,0,9 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 154094-89:
(8*1)+(7*5)+(6*4)+(5*0)+(4*9)+(3*4)+(2*8)+(1*9)=140
140 % 10 = 0
So 154094-89-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N7O5/c1-8-13-6-10(17(20)21)16(8)5-4-14-2-3-15(7-9(12)19)11(14)18(22)23/h2-3,6,11H,4-5,7H2,1H3,(H2,12,19)

154094-89-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[3-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-2-nitro-2H-imidazol-1-yl]acetamide

1.2 Other means of identification

Product number -
Other names 2-[3-[2-(2-METHYL-5-NITRO-IMIDAZOL-1-YL)ETHYL]-2-NITRO-2H-IMIDAZOL-1-Y L]ACETAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154094-89-0 SDS

154094-89-0Downstream Products

154094-89-0Relevant articles and documents

Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: A new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers

Hay,Wilson,Moselen,Palmer,Denny

, p. 381 - 391 (2007/10/02)

A series of novel bis(nitroimidazolyl)alkanecarboxamides has been prepared and evaluated for hypoxia-selective cytotoxicity and hypoxic cell radiosensitisation in vitro and in vivo. The compounds were prepared by direct coupling of preformed side chain acid and amine components, using diethyl phosphorocyanidate at room temperature. Although designed to be bis- bioreductive prodrugs of DNA cross-linking agents, none of the compounds showed evidence of DNA cross-linking activity, being equally potent against cell lines deficient and proficient in repair of cross-links. However, one of these compounds, N-[2-(2-methyl-5-nitro-1H-imidazolyl)ethyl]-4-(2-nitro-1H- imidazolyl)butanamide (10; SN 24699), showed high hypoxic selectivity as a cytotoxin (rising to 200-fold after exposure to the drug for several hours) in the repair-proficient Chinese hamster cell line AA8. This selectivity was greater than observed for the alkylating 2-nitroimidazole (4; RB 6145) (40- fold) or simple mononitroimidazoles (5-25-fold). Investigation of structure- activity relationships for hypoxic selectivity of bis(nitroimidzoles) was restricted by their low aqueous solubility, but a certain minimum separation of the two nitroimidazole units (by more than five atoms) appears desirable. All the compounds radiosensitized hypoxic cells in vitro but were little more potent as radiosensitizers than the corresponding monomeric nitroimidazoles. Compound 10 caused additional cell killing in the KHT tumor when multiple drug doses were administered in combination with a single dose of radiation. It is not yet clear whether this activity reflects hypoxic cell radiosensitization or cytotoxicity toward hypoxic cells, but this new class of bis-bioreductive agent clearly warrants further investigation.

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