1541177-24-5Relevant academic research and scientific papers
Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H?Transfer from a Nickel Hydride
Hammond, Matthew,Norton, Jack,Wang, Shuai,Yao, Chengbo
supporting information, p. 4793 - 4799 (2020/03/31)
The hydrodefluorination of CF3-substituted alkenes can be catalyzed by a nickel(II) hydride bearing a pincer ligand. The catalyst loading can be as low as 1 mol%. gem-Difluoroalkenes containing a number of functional groups can be formed in goo
Methylenation of perfluoroalkyl ketones using a Peterson olefination approach
Hamlin, Trevor A.,Kelly, Christopher B.,Cywar, Robin M.,Leadbeater, Nicholas E.
, p. 1145 - 1153 (2014/03/21)
An operationally simple, inexpensive, and rapid route for the olefination of a wide array of trifluoromethyl ketones to yield 3,3,3- trifluoromethylpropenes is reported. Using a Peterson olefination approach, the reaction gives good to excellent yields of the alkene products and can be performed without purification of the β-hydroxysilyl intermediate. The reaction can be extended to other perfluoroalkyl substituents and is easily scaled up. The alkenes prepared can be readily transformed into a variety of other perfluoroalkyl-containing compounds.
