2396-05-6

Usage

Uses

Used in Laboratory Studies:
1-(4-Dimethylaminophenyl)-2,2,2-trifluoroethanone is used as a research compound for laboratory studies, as it is a member of the trifluoroethanones and has unique chemical properties that can be explored in various chemical reactions and analyses.
Used in Preparatory Chemical Research:
1-(4-Dimethylaminophenyl)-2,2,2-trifluoroethanone is used as a starting material or intermediate in preparatory chemical research, where it can be further modified or synthesized into more complex molecules for various applications. Although it doesn't have any significant industrial or medical use currently, its potential for future applications is still being investigated.

InChI:InChI=1/C10H10F3NO/c1-14(2)8-5-3-7(4-6-8)9(15)10(11,12)13/h3-6H,1-2H3

Upstream product

• 360-92-9 N,N-diethyl-2,2,2-trifluoroacetamide 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 383-63-1 ethyl trifluoroacetate, 
• 121-69-7 N,N-dimethyl-aniline 
• 407-25-0 trifluoroacetic anhydride 
• 619-84-1 p-N,N-dimethylaminobenzoic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 201230-82-2 carbon monoxide 
• 698-70-4 4-Iodo-N,N-dimethylaniline 

Downstream Products

• 35462-64-7 Dimethyl-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-phenyl]-amine 
• 23516-79-2 4-(trifluoroacetyl)aniline 
• 75822-12-7 4-methylamino-α,α,α-trifluoroacetophenone 
• 75822-13-8 4-(2,2,2-trifluoro-1-hydroxyethyl)-N,N-dimethylaniline 
• 136346-86-6 2-[4-(dimethylamino)phenyl]-1,1,1-trifluoro-4-phenylbut-3-yn-2-ol 
• 136346-85-5 1,1,1,7,7,7-hexafluoro-2,6-di(p-dimethylaminophenyl)-2,6-dihydroxyheptan-4-one 
• 2396-09-0 β-Pentafluoraethyl-N,N-dimethylanilin 
• 2124-31-4 4'-dimethylaminoacetophenone 

Relevant academic research and scientific papers

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

A palladium-catalyzed carbonylative coupling of aryl iodides with a (trifluoromethyl)copper reagent has been developed. A wide range of substrates have been transformed into their corresponding trifluoromethyl ketones in good to excellent yields under mild conditions with high efficiency and excellent functional-group compatibility. Preliminary mechanistic investigations suggest that the transmetallation of an acylpalladium intermediate with the (trifluoromethyl)copper reagent seems to be involved in the catalytic cycle. Notably, this report represents one of the few studies on carbonylative coupling with organocopper reagents.

A simple method for the preparation of aryl trifluoromethyl ketones

4-Dimethylamino-1-trifluoroacetylpyridinium trifluoroacetate (2) is an effective, easy to handle and stable trifluoroacetylation agent. Aryl trifluormethyl ketones 4 are obtained in good yields by reaction of 2 with aromatic compounds 3 in the presence of aluminum chloride.