1541177-63-2Relevant academic research and scientific papers
Methylenation of perfluoroalkyl ketones using a Peterson olefination approach
Hamlin, Trevor A.,Kelly, Christopher B.,Cywar, Robin M.,Leadbeater, Nicholas E.
, p. 1145 - 1153 (2014/03/21)
An operationally simple, inexpensive, and rapid route for the olefination of a wide array of trifluoromethyl ketones to yield 3,3,3- trifluoromethylpropenes is reported. Using a Peterson olefination approach, the reaction gives good to excellent yields of the alkene products and can be performed without purification of the β-hydroxysilyl intermediate. The reaction can be extended to other perfluoroalkyl substituents and is easily scaled up. The alkenes prepared can be readily transformed into a variety of other perfluoroalkyl-containing compounds.
