1541197-82-3

Usage

Structure

Dioxolane ring with a bromine atom and a trifluoromethyl group The compound features a five-membered dioxolane ring structure, with a bromine atom attached to one of the carbon atoms and a trifluoromethyl group (CF3) attached to the adjacent carbon atom.

Reactivity

Highly reactive organohalide The presence of the bromine atom and the trifluoromethyl group makes 2-(3-bromo-5-(trifluoromethyl)phenyl)-[1,3]dioxolane highly reactive, allowing it to participate in various chemical reactions and form a wide range of products.

Applications

Organic synthesis and pharmaceutical research Due to its reactivity, 2-(3-bromo-5-(trifluoromethyl)phenyl)-[1,3]dioxolane is commonly used as a reagent in organic synthesis and pharmaceutical research to develop new chemical compounds and pharmaceuticals.

Safety concerns

Handle with caution 2-(3-bromo-5-(trifluoromethyl)phenyl)-[1,3]dioxolane may pose health and safety hazards if not used properly, so it is important to follow appropriate safety protocols and precautions when working with it.

Upstream product

• 477535-41-4 3-bromo-5-(trifluoromethyl)benzaldehyde 
• 107-21-1 ethylene glycol 

Downstream Products

• 1541199-06-7 (S)-3-amino-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid 
• 1541199-08-9 (S)-ethyl 3-amino-3-(3-trifluoromethyl-5-(2-hydroxypropan-2-yl)phenyl)propionate hydrochloride 
• 1541199-09-0 (3S)-ethyl 3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoate 
• 1541197-12-9 (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid 
• 1541197-86-7 3-(1-hydroxy-1-methylethyl)-5-trifluoromethylbenzaldehyde 
• 1541197-80-1 3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt 
• 1541197-84-5 2-(3-trifluoromethyl-5-[1,3]dioxolan-2-ylphenyl)propan-2-ol 

Relevant academic research and scientific papers

Ruthenium-catalyzed enantioselective C-H functionalization: A practical access to optically active indoline derivatives

Ru(II)-catalyzed enantioselective C-H activation/hydroarylation has been developed for the first time, allowing for highly enantioselective synthesis of indoline derivatives via catalytic C-H activation. Commercially available Ru(II) arene complexes and chiral α-methylamines were employed as highly enantioselective catalysts. Based on a sterically rigidified chiral transient directing group, multisubstituted indolines were produced in up to 92% yield with 96% ee. Further transformation of the resulting 4-formylindoline enables access to an optically active tricyclic compound that is of potential biological and pharmaceutical interest.

BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS

Disclosed herein are novel pharmaceutical agents which are useful as integrin receptor antagonists that mediate the pathologic processes of angiogenesis and fibrosis and as such are useful in pharmaceutical compositions and in methods for treating conditions mediated by these integrins by inhibiting or antagonizing these integrins. The novel pharmaceutical agents include those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods and intermediates useful for making the pharmaceutical agents and methods of using the pharmaceutical agents are also provided.