154136-24-0

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 145041-35-6 (2R,3S)-3-Amino-2-benzyloxy-3-phenyl-thiopropionic acid S-tert-butyl ester 
• 145041-34-5 (2R,3S)-3-Azido-2-benzyloxy-3-phenyl-thiopropionic acid S-tert-butyl ester 
• 145041-33-4 S-tert-butyl (2R,3R)-2-benzyloxy-3-hydroxy-3-phenylpropanethioate 
• 133756-18-0 S-tert-butyl 2-(benzyloxy)ethanethioate 

Downstream Products

• 124605-42-1 methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate 
• 154136-25-1 methyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanoate 

Relevant academic research and scientific papers

Highly stereocontrolled asymmetric syntheses of taxol and taxotere C-13 side chain analogues

Asymmetric aldol reaction of (+)-tricarbonyl(η6-2-trimethylsilylbenzaldehyde)chromium(0) complex (4) with titanium enolate of S-tert-butyl benzyloxyethanethioate (10) provided, after consecutive desilylation and decomplexation, anti-aldol product 15 in a highly stereo selective manner. Anti-product 15 was subsequently converted to (2R,3S)-N-benzoyl- and N-tert-butoxycarbonyl-3-phenylisoserine methyl esters (23 and 24), C-13 side chain analogues of taxol (1) and taxotere (2).