154136-25-1

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 155396-65-9 (2R,3S)-2-benzyloxy-3-tert-butoxy-carbonylamino-3-phenylpropanoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 153063-58-2 methyl (2R,3R)-2-benzyloxy-3-hydroxy-3-phenylpropanoate 
• 145041-34-5 (2R,3S)-3-Azido-2-benzyloxy-3-phenyl-thiopropionic acid S-tert-butyl ester 
• 145041-35-6 (2R,3S)-3-Amino-2-benzyloxy-3-phenyl-thiopropionic acid S-tert-butyl ester 
• 145041-33-4 S-tert-butyl (2R,3R)-2-benzyloxy-3-hydroxy-3-phenylpropanethioate 
• 133756-18-0 S-tert-butyl 2-(benzyloxy)ethanethioate 
• 175854-17-8 (2R,3S)-2-Benzyloxy-3-phenyl-3-((R)-1-phenyl-ethylamino)-propan-1-ol 
• 175854-20-3 ((1S,2R)-2-Benzyloxy-3-hydroxy-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 67-56-1 methanol 
• 154136-24-0 S-tert-butyl (2R,3S)-2-benzyloxy-3-tert-butoxycarbonylamino-3-phenylpropanethioate 

Downstream Products

• 124605-42-1 methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate 

Relevant academic research and scientific papers

PREPARATION OF β-PHENYL-ISOSERINE DERIVATIVES

A process for stereoselective synthesis of a β-phenylisoserine comprises reacting a carbonyl imine R-C=N-CO-OR1 with a protected α- oxyaldehyde X1O-CH2CHO in the presence of a chiral amine catalyst and oxidizing aldehyde s

Synthesis of optically active hydroxy amino acids via 2-O-benzylglyceraldehyde N-[(R)-1-phenylethyl]imine

N-Boc esters of 3-phenylisoserine D, norstatine E, statine P, 'methylsilastatine' G and homostatine H are prepared in 4 to 5 steps from 2-O-benzylglyceraldehyde N-[(R)-1-phenylethyl]imine 1.

Highly stereocontrolled asymmetric syntheses of taxol and taxotere C-13 side chain analogues

Asymmetric aldol reaction of (+)-tricarbonyl(η6-2-trimethylsilylbenzaldehyde)chromium(0) complex (4) with titanium enolate of S-tert-butyl benzyloxyethanethioate (10) provided, after consecutive desilylation and decomplexation, anti-aldol product 15 in a highly stereo selective manner. Anti-product 15 was subsequently converted to (2R,3S)-N-benzoyl- and N-tert-butoxycarbonyl-3-phenylisoserine methyl esters (23 and 24), C-13 side chain analogues of taxol (1) and taxotere (2).