154140-26-8

Basic information

• Product Name: <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle
• Synonyms: <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle
• CAS NO: 154140-26-8
• Molecular Weight: 339.295
• Mol File: 154140-26-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle(CAS DataBase Reference)
• NIST Chemistry Reference: <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle(154140-26-8)
• EPA Substance Registry System: <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle(154140-26-8)

Safety Data

• Hazardous Substances Data: 154140-26-8(Hazardous Substances Data)

Upstream product

• 1886-26-6 norfenfluramine 
• 814-49-3 diethyl chlorophosphate 
• 122-52-1 triethyl phosphite 

Downstream Products

• 458-24-2 Fenfluramine 

Relevant articles and documents

Syntheses of (S)-fenfluramine from (R) or (S)-1-propan-2-ol

(R) and (S)-1-propan-2-ol 3 are useful intermediates in the synthesis of fenfluramine (S)-1.They can be obtained from optically active propylene oxide (R) or (S)-7.The alcohol (R)-3 was transformed in two steps into (S)-fenfluramine using the action of ethylamine on a sulfonate (R)-4.We describe a new one-pot synthesis for (S)-fenfluramine from the azide (S)-5, which was obtained from the alcohol (R)-3 in two steps.We also propose an original and rapid procedure to transform the alcohol (S)-3 into (S)-fenfluramine via the chloride (R)-14 and the azide (S)-5, without preliminary inversion of the alcohol.All of these reactions have been achieved without any loss of chirality.Keywords - 1-propan-2-ol / fenfluramine / asymmetric synthesis / chiral methyloxirane / nucleophilic substitution