1886-26-6

Basic information

• Product Name: Norfenfluramine
• Synonyms: 1-[3-(Trifluoromethyl)phenyl]-2-aminopropane;α-Methyl-m-(trifluoromethyl)phenethylamine;[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine
• CAS NO: 1886-26-6
• Molecular Formula: C₁₀H₁₂F₃N
• Molecular Weight: 203.207189
• EINECS: 242-769-7
• Mol File: 1886-26-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 215.2 °C at 760 mmHg
• Flash Point: 88.9 °C
• Appearance: /
• Density: 1.152 g/cm³
• Vapor Pressure: 0.15mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: Norfenfluramine(CAS DataBase Reference)
• NIST Chemistry Reference: Norfenfluramine(1886-26-6)
• EPA Substance Registry System: Norfenfluramine(1886-26-6)

Safety Data

• Hazardous Substances Data: 1886-26-6(Hazardous Substances Data)

Usage

General Description

Norfenfluramine is a chemical compound that belongs to the class of amphetamine derivatives and was formerly used as an anorectic agent for the treatment of obesity. It works by increasing the release of serotonin, a neurotransmitter that regulates mood and appetite, in the brain. However, due to its potential for causing pulmonary hypertension and valvular heart disease, the drug was withdrawn from the market in the 1990s. It has also been classified as a Schedule IV controlled substance due to its potential for abuse and addiction. Norfenfluramine is no longer available for medical use and is considered a banned substance in many countries.

InChI:InChI=1/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3

Upstream product

• 135561-75-0 1-[(3′-trifluoromethyl)phenyl]-2-propanol 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 783-04-0 2-Nitro-1-<3-trifluormethyl-phenyl>-propen-(1) 

Downstream Products

• 31173-14-5 N-<2-<1-methyl-2-(3-trifluoromethyl)phenyl>ethyl>aminoethanol 
• 22444-69-5 3-[1-Methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-propan-1-ol 
• 154140-26-8 <1-methyl-2-(3-phenyl)ethyl>phosphoramidate de diethyle 
• 29865-57-4 1-m-Trifluormethylphenyl-1-nitropropan 
• 52271-35-9 N-[1-Methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-hydroxylamine 
• 248930-67-8 (2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)butanamide Hydrochloride 
• 55704-47-7 benzyl N-[1-(3-trifluoromethylphenyl) prop-2-yl] glycinate 
• 23602-78-0 benfluorex 
• 73927-52-3 3-Trifluoromethyl-benzoic acid 2-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester 
• 73927-36-3 (4-Chloro-phenoxy)-acetic acid 2-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester 
• 73927-46-5 4-Nitro-benzoic acid 2-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester 
• 73927-48-7 2-Phenyl-butyric acid 2-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester 
• 73927-45-4 Naphthalene-2-carboxylic acid 2-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester 
• 73927-37-4 (4-Chloro-phenyl)-acetic acid 2-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethylamino]-ethyl ester 

Relevant articles and documents

Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium

A hybrid organo- and biocatalytic system for the asymmetric conversion of racemic alcohols into amines was developed. Combining an organocatalyst, AZADO, an oxidant, NaOCl, and an enzyme, ω-transaminase, we implemented a one-pot oxidation-transamination sequential process in aqueous medium. The method showed broad substrate scope and was successfully applied to conventional secondary alcohols and sterically hindered β-substituted cycloalkanols, where a highly stereoselective dynamic asymmetric bioamination enabled us to set up both contiguous stereocenters with very high enantio- and diastereomeric ratio (>90% yield, >99% ee, and up to 49:1 dr).