154140-60-0Relevant academic research and scientific papers
Synthesis of 3,3-difluoro-DL-alanine and 3,3-difluoro-DL-alanine precursors
D'Orchymont
, p. 961 - 963 (2007/10/02)
The key intermediate to 3,3-difluoroalanine, 2,2-difluoro-1-ethylthioethylamine hydrobromide (2), was prepared by the Steglich and Weygand procedure. Its conversion to N-benzyloxycarbonyl-2,2-difluoro-1-ethenylethylamine (5) followed by oxidation and subsequent deprotection of the amine afforded the 3,3-difluoroalanine.
