154150-18-2

Basic information

• Product Name: (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER
• Synonyms: (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER;TERT-BUTYL 2-METHOXYPHENYLCARBAMATE;(2-MEHTOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER;N-Boc-2-Methoxyaniline;tert-Butyl N-(2-methoxyphenyl)carbamate;2-Methoxyaniline, N-BOC protected;tert-Butyl (2-methoxyphenyl)carbamate, 2-[(tert-Butoxycarbonyl)amino]anisole, N-(tert-Butoxycarbonyl)-2-methoxyaniline;N-(2-Methoxyphenyl)-carbaMic acid 1,1-diMethylethyl Ester
• CAS NO: 154150-18-2
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.27
• EINECS: 803-043-0
• Mol File: 154150-18-2.mol
• Article Data: 26

Chemical Properties

• Melting Point: 33.5-35.0°C
• Boiling Point: 276°Cat760mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.102g/cm³
• Vapor Pressure: 0.00492mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER(154150-18-2)
• EPA Substance Registry System: (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER(154150-18-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 154150-18-2(Hazardous Substances Data)

Usage

General Description

(2-Methoxyphenyl)-carbamic acid, 1,1-dimethyl ethyl ester is a chemical compound with the molecular formula C11H15NO3. It is a carbamate ester with potential use as a herbicide. It is a colorless to light-yellow liquid and is considered to be stable under normal temperatures and pressures. (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER may be hazardous to the environment and is harmful if swallowed, inhaled, or absorbed through the skin. It is important to handle and dispose of this chemical compound with caution and in accordance with safety regulations and guidelines.

InChI:InChI=1/C12H17NO3/c1-12(2,3)16-11(14)13-9-7-5-6-8-10(9)15-4/h5-8H,1-4H3,(H,13,14)

Upstream product

• 578-57-4 2-bromoanisole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 4248-19-5 tert-butyl carbazate 
• 766-51-8 2-Chloroanisole 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1026003-01-9 2-tert-Butoxycarbonylamino-3-methoxy-benzoic acid 
• 398136-42-0 tert-butyl 2-benzyl-6-methoxyphenylcarbamate 
• 398136-31-7 tert-butyl 2-ethyl-6-methoxyphenylcarbamate 
• 1584648-13-4 tert-butyl (2-methoxy-6-(5-(trifluoromethyl)picolinoyl)phenyl)carbamate 
• 1584648-55-4 tert-butyl (2-(5-chloropicolinoyl)-6-methoxyphenyl)carbamate 
• 194869-20-0 tert-butyl 2-methoxy-6-((trimethylsilyl)ethynyl)phenylcarbamate 
• 3189-22-8 7-methoxy-1H-indole 
• 398136-64-6 3-acryloyl-4-(diphenylmethyl)-1,3-benzoxazol-2(3H)-one 
• 398136-56-6 4-(diphenylmethyl)-1,3-benzoxazol-2(3H)-one 
• 398136-61-3 3-acryloyl-4-benzyl-1,3-benzoxazol-2(3H)-one 
• 398136-53-3 4-benzyl-1,3-benzoxazol-2(3H)-one 
• 53982-01-7 2-Ethyl-6-methoxyaniline 
• 398136-43-1 tert-butyl 2-(1-hydroxy-2,2-dimethylpropyl)-6-methoxyphenylcarbamate 
• 398136-51-1 2-amino-3-(diphenylmethyl)phenol 

Relevant articles and documents

N-boc protection of amines with di-tert-butyldicarbonate in water under neutral conditions in the presence of β-cyclodextrin

A new protocol for protection of aryl and aliphatic amines was developed with (Boc)2O in the presence of β-cyclodextrin in water. A catalytic amount of β-cyclodextrin is specific for activation of amines. This procedure works well on a wide variety of both electron-rich and electron-deficient amines. Georg Thieme Verlag Stuttgart.

Bis(4-benzhydryl-benzoxazol-2-yl)methane – from a Bulky NacNac Alternative to a Trianion in Alkali Metal Complexes

A novel sterically demanding bis(4-benzhydryl-benzoxazol-2-yl)methane ligand 6 (4?BzhH2BoxCH2) was gained in a straightforward six-step synthesis. Starting from this ligand monomeric [M(4-BzhH2BoxCH)] (M=Na (7), K (81)) and dimeric [{M(4-BzhH2BoxCH)}2] (M=K (82), Rb (9), Cs (10)) alkali metal complexes were synthesised by deprotonation. Abstraction of the potassium ion of 8 by reaction with 18-crown-6 resulted in the solvent separated ion pair [{(THF)2K@(18-crown-6)}{bis(4-benzhydryl-benzoxazol-2-yl)methanide}] (11), including the energetically favoured monoanionic (E,E)-(4-BzhH2BoxCH) ligand. Further reaction of 4?BzhH2BoxCH2 with three equivalents KH and two equivalents 18-crown-6 yielded polymeric [{(THF)2K@(18-crown-6)}{K@(18-crown-6)K(4-BzhBoxCH)}]n (n→∞) (12) containing a trianionic ligand. The neutral ligand and herein reported alkali complexes were characterised by single X-ray analyses identifying the latter as a promising precursor for low-valent main group complexes.

Highly efficient chemoselective N-tert butoxycarbonylation of aliphatic/aromatic/heterocyclic amines using diphenylglycoluril as organocatalyst

An efficient approach for the Chemoselective N-tert-butoxycarbonylation of a variety of amines using diphenylglycoluril as organocatalyst has been described. For the first time, a plausible mechanism for the N-tert-butoxycarbonylation has been proposed using density functional theory (DFT) calculations supported by NMR studies. The reusability of the organocatalyst and observation of the desired N-Boc protected amines being formed without the formation of side products like urea, oxazolidinone, isocyanate, and N, N-di-Boc derivatives makes the present protocol desirable.