154153-26-1Relevant academic research and scientific papers
Anti-influenza virus activities of 2-alkoxyimino-N-(2-isoxazolin-3-ylmethyl)acetamides
Kai, Hiroyuki,Matsumoto, Hiroshi,Hattori, Naohiko,Takase, Akira,Fujiwara, Tamio,Sugimoto, Hirohiko
, p. 1997 - 2000 (2007/10/03)
A series of 2-alkoxyimino-N-(2-isoxazolin-3-ylmethyl)acetamides and related compounds were synthesized and their antiviral activities against human influenza A virus were assessed. Studies of the structure-activity relationships revealed the strongest antiviral activity when position-5 of the isoxazoline ring was substituted with a tert-butyl group. When the alkoxyimino moiety was substituted with a methyl, ethyl, isopropyl or allyl group, good antiviral activity was obtained. Among the geometrical isomers at the oxime moiety, the E-isomers were more active than the Z-isomers. Among the compounds examined, (E)-2-allyloxyimino-2-cyano-N-(5-tert-butyl-2-isoxazolin-3-ylmethyl)acetamide (1j) was the most active inhibitor with an EC50 of 3 μg/mL in vitro.
