15420-02-7

Basic information

• Product Name: 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE
• Synonyms: 4,4(1,3,4-OXADIAZOLE-2,5-DIYL)BIS-PYRIDINE;2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE;4-[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]pyridine
• CAS NO: 15420-02-7
• Molecular Formula: C₁₂H₈N₄O
• Molecular Weight: 224.22
• Product Categories: pharmacetical
• Mol File: 15420-02-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 184.5-185 °C
• Boiling Point: 453.8°Cat760mmHg
• Flash Point: 240.3°C
• Appearance: /
• Density: 1.276g/cm³
• Vapor Pressure: 5.39E-08mmHg at 25°C
• Refractive Index: 1.599
• PKA: 1.44±0.10(Predicted)
• CAS DataBase Reference: 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE(15420-02-7)
• EPA Substance Registry System: 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE(15420-02-7)

Safety Data

• Hazardous Substances Data: 15420-02-7(Hazardous Substances Data)

Usage

General Description

2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE is a chemical compound with the chemical formula C14H10N4O. It is a heterocyclic aromatic compound that consists of a central 1,3,4-oxadiazole ring with two 4-pyridyl groups attached at the 2 and 5 positions. 2,5-BIS(4-PYRIDYL)-1,3,4-OXADIAZOLE has been used in various research applications, including as a building block in the synthesis of organic materials and pharmaceuticals. It has also been investigated for its potential biological activities, such as its antioxidant and neuroprotective properties. Additionally, it has been studied for its potential use in the development of fluorescent sensors for metal ions.

InChI:InChI=1/C12H8N4O/c1-5-13-6-2-9(1)11-15-16-12(17-11)10-3-7-14-8-4-10/h1-8H

Upstream product

• 4329-75-3 N,N'-bis(isonicotinoyl)hydrazine 
• 55-22-1 pyridine-4-carboxylic acid 
• 57654-36-1 3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine 
• 54-85-3 isoniazid 
• 4813-04-1 isonicotinic acid isopropylidenehydrazide 

Downstream Products

• 1346004-08-7 ([Zn(2,5-bis(4-pyridyl)-1,3,4-oxadiazole)(terephthalate)](CH₃OH))n 

Relevant articles and documents

Crystal structures of two substituted 2,5-diaryl-1,3,4-oxadiazoles

The crystal structures of 2,5-di(4-pyridyl)-1,3,4-oxadiazole, I, and 2-(4-cyanophenyl)-5-(4-dimethylaminophenyl)-1,3,4-oxadiazole, II, were determined from single crystal data (I: monoclinic, C2/c (no. 15), a = 5.3129(9) ?, b = 12.142(3) ?, c = 16.771(3) ?, β = 93.41(2)°, Rall = 0.0774; II: triclinic, P1? (no. 2), a = 7.3908(12) ?, b = 8.7992(15) ?, c = 12.036(2) ?, α = 77.04(2)°, β = 89.29(2)°, γ = 87.58(2)°, Rall = 0.0552). In both structures the formation of stacks of the almost planar molecules is observed as known for other oxadiazoles. These compounds exhibit differences to other substituted 2,5-diaryl-1,3,4-oxadiazoles in the crystalline structure.

Study of heterogeneous catalysis by iron-squarate based 3d metal organic framework for the transformation of tetrazines to oxadiazole derivatives

We present here a simple, milder, and environmentally benign heterogeneous catalytic method for the transformation of tetrazines to oxadiazole derivatives at room temperature (25 °C) using our earlier synthesized iron-squarate based 3D metal organic framework, [Fe3(OH)3(C 4O4)(C4O4)0.5] n (FeSq-MOF).

2,5-SUBSTITUTED OXAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER

Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.