154201-52-2Relevant articles and documents
Synthesis and local anaesthetic activity of some 2-aminoacetylamino-3-carbetoxy/anilido-4,5,6,7-tetrahydro-benzothiophenes
Gadad, A K,Kumar, Hemant,Shishoo, C J,Khazi, I M,Mahajanshetti, C S
, p. 298 - 301 (2007/10/02)
Twenty new 2-substituted aminoacetylamino-3-carbetoxy/anilido-4,5,6,7-tetrahydrobenzothiophenes (4a-4t) have been synthesised with a view to studying the effect of structural modification of carticaine (B) on the local anaesthetic activity and evaluated by Sollman's method as well as Bulbring and Wajda method using lignocaine hydrochloride as a standard.All the tested compounds show moderate to good activity and 4a has been found to be the most active drug comparable to the standard.