15421-84-8 Hazards Identification
Pictogram(s):
Signal:
Warning
GHS Hazard Statements:
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes:
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories:
Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)
15421-84-8 Usage
Chemical Properties
White or almost white, crystalline powder
Originator
Rocornal,Mochida,Japan,1978
Uses
Vasodilator;PDGF antagonist
Manufacturing Process
8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30
cc of water and 7.3 g of diethylamine added. After 2 hours heating with
stirring, the mixture was concentrated under vacuum. The residue was
recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7-
diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to
104°C. The hydrochloride produced in the usual manner had a melting point
of 212°C.
Therapeutic Function
Coronary vasodilator
Safety Profile
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. An experimental
teratogen. Other experimental reproductive
effects. A coronary vasodilator. When
heated to decomposition it emits toxic
fumes of NOx. See also MINES.
Check Digit Verification of cas no
The CAS Registry Mumber 15421-84-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,4,2 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 15421-84:
(7*1)+(6*5)+(5*4)+(4*2)+(3*1)+(2*8)+(1*4)=88
88 % 10 = 8
So 15421-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3
15421-84-8Relevant academic research and scientific papers
CD40 signal blocking agent
-
, (2008/06/13)
A CD40 signal blocking agent comprising, as an active ingredient, s-triazolo[1,5-a]pyrimidine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof, is disclosed
