154221-18-8Relevant academic research and scientific papers
Simple and efficient nickel-catalyzed cross-coupling reaction of alkenylalanes with alkynyl halides for synthesis of conjugated enynes
Xiao, Hong-Liu,Zhang, Gang,Luo, Rui-Qiang,Li, Qing-Han
, (2021/11/23)
A NiCl2(PPh3)2/XantPhos catalyzed synthesis of conjugated enynes by the cross-coupling of terminal alkynyl halides with alkenylaluminum reagents at room temperature in DME solvent was developed under mild reaction conditions. The aryls bearing electron-donating or electron-withdrawing groups in alkynylhalides give the corresponding cross-coupling products conjugated enynes in good to excellent isolated yields up to 97%. This process was simple and easily performed, which provides an efficient method for the synthesis of conjugated enynes derivatives. On the basis of the experimental results, a possible catalytic cycle has been proposed.
Palladium-catalysed Dehydration of Propynyl Alcohols with Tin(II) Chloride
Masuyama, Yoshiro,Takahara, Jun P.,Hashimoto, Kazumi,Kurusu, Yasuhiko
, p. 1219 - 1220 (2007/10/02)
α,γ-Disubstituted propynyl alcohols having a proton on 1-position of α-substituent have been dehydrated using PdCl2(PPh3)2 and SnCl2 in 1,3-dimethylimidazolidin-2-one under neutral conditions to produce 1,4-disubstituted (Z)-but-3-en-1-ynes stereoselectiv
