154223-99-1

Upstream product

• 610-66-2 2-nitro-benzeneacetonitrile 
• 874-60-2 4-methyl-benzoyl chloride 
• 154224-24-5 2-(2-nitrophenyl)acetamide oxime 

Downstream Products

• 154224-03-0 3-(2-Nitro-benzyl)-5-p-tolyl-[1,2,4]oxadiazole 
• 154224-16-5 N-(1H-Indol-2-yl)-4-methyl-benzamide 
• 154224-15-4 N-[2-(2-Benzoylamino-phenyl)-1-imino-ethyl]-4-methyl-benzamide 
• 154224-13-2 N-[2-(5-p-Tolyl-[1,2,4]oxadiazol-3-ylmethyl)-phenyl]-benzamide 
• 154224-07-4 2-(5-p-Tolyl-[1,2,4]oxadiazol-3-ylmethyl)-phenylamine 

Relevant academic research and scientific papers

Reductive Formation of 2-(Benzoylamino)indole from 3-(2-Aminobenzyl)-5-phenyl-1,2,4-oxadiazole and Its Transfomation to 6-Phenyl-8H-pyrimido-diindole, a New Heterocyclic Ring System

Catalytic hydrogenation of 5-substituted 3-(2-aminobenzyl)-1,2,4-oxadiazoles 7 give 2-(acylamino)indoles 10.Treatment of 2-(benzoylamino)indoles 10a-c with acid leads to the novel 6-phenyl-8H-pyrimidodiindoles 19a-c.A route for the new ring formation is proposed.Catalytic hydrogenation of 19a (Raney nickel, 70 deg C, atmospheric pressure) saturates the 6-phenyl ring but leaves the pentacyclic ring system intact.The structure of 19a is confirmed by an X-ray crystallographic analysis. - Key Words: 1,2,4-Oxadiazoles, 5-substituted, 3-(2-aminobenzyl)- / Indoles, 2-(acylamino)- / 8H-Pyrimidodiindoles, 6-aryl