154224-03-0Relevant articles and documents
Reductive Formation of 2-(Benzoylamino)indole from 3-(2-Aminobenzyl)-5-phenyl-1,2,4-oxadiazole and Its Transfomation to 6-Phenyl-8H-pyrimido-diindole, a New Heterocyclic Ring System
Bata, Imre,Korbonits, Dezsoe,Kolonits, Pal,Podanyi, Benjamin,Takacsy-Eroes, Tuende,Simon, Kalman
, p. 1835 - 1842 (2007/10/02)
Catalytic hydrogenation of 5-substituted 3-(2-aminobenzyl)-1,2,4-oxadiazoles 7 give 2-(acylamino)indoles 10.Treatment of 2-(benzoylamino)indoles 10a-c with acid leads to the novel 6-phenyl-8H-pyrimidodiindoles 19a-c.A route for the new ring formation is proposed.Catalytic hydrogenation of 19a (Raney nickel, 70 deg C, atmospheric pressure) saturates the 6-phenyl ring but leaves the pentacyclic ring system intact.The structure of 19a is confirmed by an X-ray crystallographic analysis. - Key Words: 1,2,4-Oxadiazoles, 5-substituted, 3-(2-aminobenzyl)- / Indoles, 2-(acylamino)- / 8H-Pyrimidodiindoles, 6-aryl