1542230-77-2Relevant academic research and scientific papers
Synthesis method of oxazolidinone
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Paragraph 0080-0083; 0135-0136, (2021/08/06)
The invention discloses a synthesis method of oxazolidinone, which belongs to the technical field of organic catalysis. The invention provides a method for catalyzing glycidyl and isocyanate to generate oxazolidinone by utilizing bifunctionality of a hydr
4-Hydroxymethyl-substituted oxazolidinone synthesis by tetraarylphosphonium salt-catalyzed reactions of glycidols with isocyanates
Toda, Yasunori,Tanaka, Shoya,Gomyou, Shuto,Kikuchi, Ayaka,Suga, Hiroyuki
supporting information, p. 5761 - 5764 (2019/05/24)
Preparation of 4-hydroxymethyl-substituted oxazolidinones including optically active ones, in which tetraarylphosphonium salts catalyze the reaction of glycidol with isocyanates effectively, is described. The neutral catalysis facilitates glycidol additio
Pd-catalyzed intramolecular aminohydroxylation of alkenes with hydrogen peroxide as oxidant and water as nucleophile
Zhu, Haitao,Chen, Pinhong,Liu, Guosheng
supporting information, p. 1766 - 1769 (2014/03/21)
A palladium-catalyzed intramolecular aminohydroxylation of alkenes was developed, in which H2O2 was applied as the sole oxidant. A variety of related alkyl alcohols could be successfully obtained with good yields and excellent diastereoselectivities, which directly derived from oxidation cleavage of alkyl C-Pd bond by H2O2. Facile transformation of these products provided a powerful tool toward the synthesis of 2-amino-1,3-diols and 3-ol amino acids. Preliminary mechanistic studies revealed that major nucleophilic attack of water (SN2 type) at high-valent Pd center contributes to the final C-O(H) bond formation.
