1542256-63-2Relevant academic research and scientific papers
Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and β-amyloid aggregation inhibitors
Dadashpour, Sakineh,Kucukkilinc, Tuba Tuylu,Tan, Oya Unsal,Ozadali, Keriman,Irannejad, Hamid,Emami, Saeed
, p. 179 - 187 (2015/03/14)
In order to find novel cyclooxygenase (COX)-2 inhibitors for treating inflammatory-based diseases such as Alzheimer's disease (AD), an ethyl carboxylate side chain was added to 5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors
Irannejad, Hamid,Kebriaieezadeh, Abbas,Zarghi, Afshin,Montazer-Sadegh, Farhad,Shafiee, Abbas,Assadieskandar, Amir,Amini, Mohsen
, p. 865 - 873 (2014/02/14)
A series of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine derivatives were synthesized and their COX-1/COX-2 inhibitory activity as well as in vivo anti-inflammatory and analgesic effects were evaluated. All of compounds showed strong inhibitio
