1542264-08-3Relevant academic research and scientific papers
Highly Stereoselective Synthesis of Fluoroalkene Dipeptides via the Novel Chromium(II)-Mediated Carbon-Fluorine Bond Cleavage/New Carbon-Carbon Bond Formation
Nihei, Takashi,Nishi, Yuji,Ikeda, Natsumi,Yokotani, Saya,Ishihara, Takashi,Arimitsu, Satoru,Konno, Tsutomu
, p. 865 - 881 (2016/03/12)
An efficient chromium(II)-mediated reductive coupling reaction of various CBrF2-containing molecules and aldehydes has been developed. This reaction proceeds presumably via the monofluorinated dichromium(III) intermediate generated by the carbon-fluorine bond activation, and provides a general and straightforward access to synthesize a variety of (E)- or (Z)-β-fluoroallylic alcohols in a highly stereoselective manner. Based on the novel reductive coupling, four types of fluoroalkene dipeptide analogues could be stereoselectively prepared.
Stereocontrolled generation of nucleophilic (Z)- or (E)-α- fluoroalkenylchromium reagents via carbon-fluorine bond activation: Highly stereoselective synthesis of (E)- or (Z)-β-fluoroallylic alcohols
Nihei, Takashi,Yokotani, Saya,Ishihara, Takashi,Konno, Tsutomu
, p. 1543 - 1545 (2014/02/14)
Highly nucleophilic (Z)- or (E)-α-fluoroalkenylchromium species could be generated in a stereoselective manner via C-F bond activation of CBrF 2-containing molecules, and they reacted smoothly with various aldehydes to give (E)- or (Z)-β-fluoroallylic alcohol derivatives in high yields, respectively. The Royal Society of Chemistry.
