154229-20-6

Basic information

• Product Name: Anhydro Abiraterone
• Synonyms: Anhydro Abiraterone;Abiraterone Acetate IMP
• CAS NO: 154229-20-6
• Molecular Formula: C24H29N
• Molecular Weight: 331.49376
• Mol File: 154229-20-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 475.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.10±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 5.31±0.12(Predicted)
• CAS DataBase Reference: Anhydro Abiraterone(CAS DataBase Reference)
• NIST Chemistry Reference: Anhydro Abiraterone(154229-20-6)
• EPA Substance Registry System: Anhydro Abiraterone(154229-20-6)

Safety Data

• Hazardous Substances Data: 154229-20-6(Hazardous Substances Data)

Usage

Uses

Anhydro Abiraterone is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.

Upstream product

• 89878-14-8 3-Diethylboranylpyridine 
• 154229-36-4 androsta-3,5,16-trien-17-yl trifluoromethanesulfonate 
• 497-19-8 sodium carbonate 
• 853-23-6 prasterone acetate 

Relevant articles and documents

17-substituted steroids useful in cancer treatment

Compounds of the general formula (1) STR1 wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R 14 represents a hydrogen atom and R 15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R 14 and R 15 together represent a double bond, and R 16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or phannaceutically acceptable acid addition salts, are useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.