154229-36-4

Basic information

• Product Name: Androsta-3,5,16-trien-17-ol Trifluoromethanesulfonate
• Synonyms: Androsta-3,5,16-trien-17-ol Trifluoromethanesulfonate;Androsta-3,5,16-trien-17-ol TrifluoroMethanesulfonate Discontinued
• CAS NO: 154229-36-4
• Molecular Formula: C₂₀H₂₅F₃O₃S
• Molecular Weight: 402.4709096
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 154229-36-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 458.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Androsta-3,5,16-trien-17-ol Trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Androsta-3,5,16-trien-17-ol Trifluoromethanesulfonate(154229-36-4)
• EPA Substance Registry System: Androsta-3,5,16-trien-17-ol Trifluoromethanesulfonate(154229-36-4)

Safety Data

• Hazardous Substances Data: 154229-36-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Syrup

Uses

An byproduct formed during the synthesis of Abiraterone Acetate

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 853-23-6 prasterone acetate 
• 115375-60-5 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate 
• 53-43-0 dehydroepiandrosterone 

Downstream Products

• 154229-20-6 17-(3-pyridyl)androsta-3,5,16-triene 

Relevant articles and documents

PROCESS FOR MAKING THE 17-TRIFLATE INTERMEDIATE OF ABIRATERONE-3-ACETATE

The present invention relates to a process for making the compound 3β-acetoxy- androsta-5,16-dien-17-yl trifluoromethanesulfonate of formula (5) and is characterized in that dehydroepiandrosterone-3-acetate of formula (2) is reacted with a triflating agent, preferably trifluoromethanesulfonic anhydride, in an inert solvent in the absence of an organic base.

17-substituted steroids useful in cancer treatment

Compounds of the general formula (1) STR1 wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R 14 represents a hydrogen atom and R 15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R 14 and R 15 together represent a double bond, and R 16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or phannaceutically acceptable acid addition salts, are useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.