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(2S,3S)- 3-hydroxy-2-PyrrolidineMethanol hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

154278-84-9

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154278-84-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 154278-84-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,2,7 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 154278-84:
(8*1)+(7*5)+(6*4)+(5*2)+(4*7)+(3*8)+(2*8)+(1*4)=149
149 % 10 = 9
So 154278-84-9 is a valid CAS Registry Number.

154278-84-9Downstream Products

154278-84-9Relevant academic research and scientific papers

Protecting-group-free synthesis of 2-deoxy-aza-sugars

Dangerfield, Emma Marie,Plunkett, Catherine Heather,Stocker, Bridget Louise,Timmer, Mattie Simon Maria

, p. 5298 - 5307 (2009)

The protecting-group-free asymmetric synthesis of 1,2,4-trideoxy-1,4-imino- L-xylitol is readily achieved in five steps from 2-deoxy-D-ribose and with an overall yield of 48%. Key in this synthesis is the application of our recently developed Vasella-redu

7-SUBSTITUTED 1-ARYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF

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Paragraph 0831-0833, (2019/09/06)

The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.

SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY

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Page/Page column 112; 197; 198; 208; 209; 210, (2018/07/29)

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.

DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS

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, (2016/02/29)

The present application relates to certain difluoropyrrolidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.

METHODS FOR THE PREPARATION OF ALKENYLAMINES, CYCLIC CARBAMATES OR DITHIOCARBAMATES, AND AMINOALCOHOLS OR AMINOTHIOLS

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Page/Page column 50, (2010/04/28)

A method for preparing an alkenylamine, or a salt, solvate or hydrate thereof, is disclosed. The method comprises reacting a alogen-substituted cyclic acetal or a derivative thereof under particular conditions to provide the alkenylamine, which may be optionally converted into a salt, solvate or hydrate thereof. A method for preparing a cyclic carbamate or cyclic dithiocarbamate, or a salt, solvate or hydrate thereof, is also disclosed. The method comprises reacting an alkenylamine under particular conditions to provide the cyclic carbamate or cyclic dithiocarbamate, which may be optionally converted into a salt, solvate or hydrate thereof. A method for preparing a 1,2-aminoalcohol or 1,2-aminothiol, or a salt, solvate or hydrate thereof, is also disclosed. The method comprises forming a cyclic carbamate or cyclic dithiocarbamate from an alkenylamine, and deprotecting the cyclic carbamate or cyclic dithiocarbamate to provide the 1,2-aminoalcohol or 1,2-aminothiol, which may optionally be converted into a salt, solvate or hydrate thereof.

Nucleophilic additions to cyclic nitrones en route to iminocyclitols - Total syntheses of DMDP, 6-deoxy-DMDP, DAB-1, CYB-3, nectrisine, and radicamine B

Merino, Pedro,Delso, Ignacio,Tejero, Tomas,Cardona, Francesca,Marradi, Marco,Faggi, Enrico,Parmeggiani, Camilla,Goti, Andrea

experimental part, p. 2929 - 2947 (2009/04/06)

Highly diastereoselective nucleophilic additions to cyclic nitrones derived from L-malic acid and D-arabinose have been used for the construction of enantiomerically pure polyhydroxylated pyrrolidines. The synthetic strategy adopted was based on an oxidat

AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE

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Page/Page column 132, (2008/06/13)

The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS

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Page/Page column 138-139, (2008/06/13)

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

A new stereospecific synthesis of 1,2,4-Trideoxy-1,4-imino-D-erythro-pentitol

Malle, Birgitte Molholm,Lundt, Inge,Furneaux, Richard H.

, p. 573 - 583 (2007/10/03)

1,2,4-Trideoxy-1,4-imino-D-erythro-pentitol [(2R,3S)-3-hydroxy-2-hydroxymethylpyrrolidine] (4) was synthesised from 2,5-di-O-tosyl-D-ribono-1,4-lactone in 42 % overall yield. The key steps were deoxygenation at C-2 and a stereospecific inversion of the co

Chromium(II) chloride-mediated coupling reactions of Garner aldehyde with allyl bromides: Facile asymmetric synthesis of (2R,3S)-3-hydroxy-2-hydroxymethylpyrrolidine

Aoyagi, Yutaka,Inaba, Haruko,Hiraiwa, Yukiko,Kuroda, Asako,Ohta, Akihiro

, p. 3975 - 3978 (2007/10/03)

Chromium(II) chloride-mediated coupling reactions of 1,1-dimethylethyl (S)- and (R)-4-formyl-2,2-dimethyloxazolidine-3-carboxylates [(S)- and (R)-Garner aldehydes] (1a,b) with allyl bromides 2a-c proceeded with moderate to good stereoselectivity to give t

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